Horm Metab Res 2009; 41(10): 785-788
DOI: 10.1055/s-0029-1224200
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Tumor Size of Conn's Adenoma and Comorbidities

E. Born-Frontsberg1 , M. Reincke2 , F. Beuschlein2 , M. Quinkler1 For the participants of the German Conn's Registry
  • 1Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany
  • 2Medizinische Klinik Innenstadt, Ludwig-Maximilians-University Munich, Munich, Germany
Further Information

Publication History

received 31.03.2009

accepted 12.05.2009

Publication Date:
22 June 2009 (online)


Primary aldosteronism (PA) is associated with vascular end organ damage. The aim of the study was to evaluate differences regarding comorbidities depending on tumor size in patients with aldosterone producing adenoma (APA). The retrospective cross-sectional study was done by collection from 6 German centers (German Conn's registry) between 1990 and 2007. Among the 640 registered patients with PA, 60 operated patients with APA were analyzed. The main outcome of measures was the comorbidities depending on tumor size. Thirty-one patients (17 men, 14 women) had an adenoma size <20 mm, and 29 patients (10 men, 19 women) had an adenoma size≥20 mm. There was no difference in age, preoperative potassium, aldosterone, or creatinine levels, preoperative systolic and diastolic blood pressure, or duration of hypertension between the two groups. In the group with APA <20 mm, cerebrovascular events occurred with a prevalence of 12.9%, cardiac events 16.1%, peripheral vascular events 25.8%, renal insufficiency 16.1%, and sleep apnea 6.4%, respectively. There was no significant difference in comorbidities compared to the group with APA≥20 mm. Subgroup analysis (n=22) of follow-up data on post-operative systolic and diastolic blood pressure showed no significant difference between these subgroups with regard to potassium, aldosterone or creatinine levels, blood pressure, duration of hypertension, or comorbidities. Our data indicate a high prevalence of comorbidities in patients with APA. However, adenoma size was not correlated with cardio- and cerebrovascular comorbidities, and does not seem to be a prognostic factor for blood pressure outcome.



Dr. M. Quinkler, MD 

Clinical Endocrinology

Internal Medicine

Centre for Gastroenterology Hepatology and Endocrinology

Charité Campus Mitte

Charité University Medicine Berlin

Charitéplatz 1

10117 Berlin


Phone: +49/30/45051 4152

Fax: +49/30/45051 4952

Email: [email protected]