Aerobic High Intensity One-Legged Interval Cycling Improves Peak Oxygen Uptake in Chronic Obstructive Pulmonary Disease Patients; No Additional Effect from Hyperoxia

Abstract

The aim of the present study was to investigate whether hyperoxic aerobic high intensity one-legged interval cycling improves peak oxygen uptake (V˙O_2peak) compared to normoxic training in patients with severe chronic obstructive pulmonary disease, and to evaluate the acute effect of hyperoxia during one- and two-legged peak exercise testing. Twelve COPD patients were recruited to perform 3 training sessions per week for 8 weeks in hyperoxia (n=7) or normoxia (n=5). Each leg was trained 4×4 min at 85–95% of the one-legged peak heart rate. One-legged V˙O_2peak increased in the hyperoxia and normoxia training groups by 24 and 15% (16.1(13.2)–20.0(11.3) and 17.4(15.1)–20.0(6.7) mL·kg^-1·min^-1) respectively. The corresponding increases in V˙O_2peak during two-legged testing were 14% in both groups (20.1(11.5)–22.9(10.6) and 18.8(8.5)–21.4(7.3) mL·kg^-1·min^-1). There were no differences between groups from pre- to post-training. Nor were there any differences between acute hyperoxia and normoxia at the pre- or post-peak exercise test. One-legged aerobic high intensity interval cycling significantly increases V˙O_2peak in COPD patients. However, breathing supplemental oxygen during training or testing does not appear to improve V˙O_2peak above the level attained by breathing ambient air.

Key words

COPD - endurance - reduced muscle mass - 4×4 min - V˙O_2peak

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