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Int J Sports Med 2010; 31(3): 213-217
DOI: 10.1055/s-0029-1243256
Genetics & Molecular Biology

© Georg Thieme Verlag KG Stuttgart · New York

CK-MM Gene Polymorphism Does not Influence the Blood CK Activity Levels After Exhaustive Eccentric Exercise

C. Yamin1 , 2 , J. Oliveira2 , Y. Meckel1 , N. Eynon1 , 2 , M. Sagiv1 , 2 , M. Ayalon1 , A. J. Alves1 , 2 , J. A. Duarte2
  • 1Zinman College of Physical Education and Sport Sciences at the Wingate Institute, Netanya, Israel
  • 2CIAFEL, Faculty of Sport, University of Porto, Portugal
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Publication History

accepted after revision November 11, 2009

Publication Date:
15 February 2010 (online)

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Abstract

Gene variants, such as creatine kinase (CK) polymorphisms, have been suggested to explain the inter-individual blood CK response to eccentric exercise. However, since this association is still doubtful, the purpose of this study was to analyse the relationship between the magnitudes of the CK response to exercise with the occurrence of muscle CK-MM NcoI polymorphism in young healthy subjects. Blood CK activity was assessed in 70 subjects immediately before and 3, 24, 48, 72, 96, 120, 168 h after strenuous eccentric exercise. Based on the amount of CK release by each subject, the sample was distributed in quartiles and the genotype and allele frequency distribution was compared among quartiles. Despite the inter-individual variability of CK response observed between subjects, there were no differences in genotype and allele frequencies among quartiles. The results allowed us to conclude that CK response after exhaustive eccentric exercise is not associated with CK-MM Ncol polymorphism.

Key words

Quartiles - genotype - inter-individual variability - muscle damage

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Correspondence

Prof. Jose Alberto Duarte

University of Porto Sport Biology

R. Dr. Placido Costa 91

4200-450 Porto

Portugal

Phone: +351919422122

Fax: +351225500689

Email: jarduarte@fade.up.pt

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