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Horm Metab Res 2010; 42(6): 416-423
DOI: 10.1055/s-0029-1243602
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© Georg Thieme Verlag KG Stuttgart · New York

Aberrant Hormone Receptors in Primary Aldosteronism

T. L. Mazzuco1 , S. Grunenwald1 , A. Lampron1 , I. Bourdeau1 , A. Lacroix1
  • 1Division of Endocrinology, Department of Medicine, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Université de Montréal, Montréal, Canada
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Publikationsverlauf

received 13.10.2009

accepted 23.11.2009

Publikationsdatum:
07. Januar 2010 (online)

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Abstract

The mechanisms involved in the renin-independent regulation of aldosterone secretion in primary aldosteronism are poorly understood. In ACTH-independent Cushing's syndrome, cortisol secretion can be regulated by the aberrant expression of G-protein coupled receptors (GPCRs) in unilateral tumors and bilateral macronodular adrenal hyperplasia. By analogy, some recent studies identified overexpression or function of several GPCR as a potential cause for excess aldosterone production in some aldosteronomas and in bilateral idiopathic hyperaldosteronism. Initial studies have used in vitro techniques, while the clinical aldosterone responses were not assessed. More recently, several receptors have been shown to be expressed in aldosterone-producing adrenal tumors in vitro and to regulate aberrantly renin-independent aldosterone secretion in vivo. The prevalence of aberrant hormone receptors in primary aldosteronism could be elevated, but larger systematic studies are required to establish its true frequency. The identification of aberrant adrenal GPCRs by in vivo functional studies offers the potential for novel pharmacological therapies that either suppress the endogenous ligands or block the receptor with specific antagonists.

Key words

primary aldosteronism - adrenal glands - G-protein coupled receptors - aldosterone

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