Intensivmedizin up2date 2010; 6(2): 121-134
DOI: 10.1055/s-0029-1243980
Internistische Intensivmedizin

© Georg Thieme Verlag KG Stuttgart · New York

Perioperatives akutes Koronarsyndrom

Tilmann  Schwab, Hans-Jörg  Busch
Further Information

Publication History

Publication Date:
21 April 2010 (online)

Kernaussagen

Das perioperative akute Koronarsyndrom ist eine große Herausforderung für alle begleitenden Disziplinen. Der perioperative Myokardinfarkt hat eine sehr ernste Prognose. Die Gesamtmortalität der Patienten mit einer KHK, die nach einem größeren, nicht kardiochirurgischen Eingriff einen Troponinanstieg zeigten, liegt bei durchschnittlich 22 % [51] [53] und ist somit deutlich höher als beim akuten Koronarsyndrom [68]. Ein großes Augenmerk ist besonders auf Prävention und Risikoabschätzung zu legen. So könnte mit einer vorgeschalteten Diagnostik das operative als auch das kardiale Risiko deutlich reduziert werden. Nicht nur eine operationsbegleitende präventive Medikation und angepasste Narkoseführung sorgen für weniger Probleme, sondern auch und gerade eine entsprechende Sensibilisierung des Personals. Denn die klassischen Symptome des akuten Koronarsyndroms sind in der postoperativen Phase nur schwach ausgeprägt. Allzu oft sind die Symptome überlagert oder werden falsch interpretiert. Im Vordergrund steht also das klinische Erkennen eines akut erkrankten Patienten, um beim geringsten Verdacht auf ein kardiales Ereignis möglichst schnell eine zielgerichtete Diagnostik einzuleiten.

Die Diagnostik besteht primär aus den hämodynamischen Parametern, einem 12-Kanal-EKG und der Bestimmung der Herzenzyme. Verdichten sich die Hinweise, muss man den Patienten konsequent überwachen und umgehend einen interventionellen Kardiologen hinzuziehen. Kurze Wege zur raschen Intervention bedürfen einer entsprechenden Logistik mit strukturierten Abläufen. Nur in gemeinsamer Diskussion und bei Abwägung der Risiken einer Intervention gegenüber einer konservativeren Vorgehensweise kann eine sinnvolle, zielgerichtete Therapie ausgearbeitet werden.

Literatur

  • 1 Thygesen K, Alpert J S, White H D. Universal definition of myocardial infarction.  Eur Heart J. 2007;  28 2525-2538
  • 2 Devereaux P J, Goldman L, Cook D J. et al . Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk.  CMAJ. 2005;  173 627-634
  • 3 Priebe H J. Triggers of perioperative myocardial ischaemia and infarction.  Br J Anaesth. 2004;  93 9-20
  • 4 Priebe H J. Perioperative myocardial infarction-aetiology and prevention.  Br J Anaesth. 2005;  95 3-19
  • 5 Goldman L, Caldera D, Nussbaum S. et al . Multifactorial index of cardiac risk in noncardiac surgical procedures.  N Engl J Med. 1977;  297 845
  • 6 Horlocker T T. et al . Risk Assessment of Hemorrhagic Complications Associated With Nonsteroidal Antiinflammatory Medications in Ambulatory Pain Clinic Patients Undergoing Epidural Steroid Injection.  Anesth Analg. 2002;  95 1691-1697
  • 7 Ferrari E, Benhamou M, Cerboni P, Marcel B. Coronary Syndromes Following Aspirin Withdrawal: a Special Risk for Late Stent Thrombosis.  J Am Coll Cardiol. 2005;  45 456-459
  • 8 Collet J P. et al . Impact of Prior Use Or Recent Withdrawal of Oral Antiplatelet Agents on Acute Coronary Syndromes.  Circulation. 2004;  110 2361-2367
  • 9 Chen M S, Bhatt D L. Highlights of the 2002 Update to the 2000 American College of Cardiology/American Heart Association Acute Coronary Syndrome Guidelines.  Cardiol Rev. 2003;  11 113-121
  • 10 Grines C L. et al . Prevention of Premature Discontinuation of Dual Antiplatelet Therapy in Patients With Coronary Artery Stents. A Science Advisory From the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, With Representation From the American College of Physicians.  Circulation. 2007;  115 813-818
  • 11 Le Manach Y, Perel A, Coriat P. et al . Early and delayed myocardial infarction after abdominal aortic surgery.  Anesthesiology. 2005;  102 885-891
  • 12 Landesberg G, Shatz V, Akopnik I. et al . Association of cardiac troponin, CK-MB, and postoperative myocardial ischemia with long-term survival after major vascular surgery.  J Am Coll Cardiol. 2003;  42 1547-1554
  • 13 Fleisher L A. Strategies to reduce cardiac risk in noncardiac surgery: where are we in 2005?.  Anesthesiology. 2005;  102 881-882
  • 14 Eagle K A, Berger P B, Calkins H. et al . ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery – executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.  Circulation. 2002;  105 1257-1267
  • 15 Leitlinie der ESC u. ESA.  Eur Heart J. 2009;  22 2769-2812
  • 16 Lee T H, Marcantonio E R, Mangione C M. et al . Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery.  Circulation. 1999;  100 1043-1049
  • 17 Filipovic M, Skarvan K, Seeberger M D. Management kardialer Risikopatienten vor nicht-herzchirurgischen Eingriffen.  Schweiz Med Forum. 2002;  2 297-301
  • 18 Kertai M D, Boersma E, Bax J J. et al . A meta-analysis comparing the prognostic accuracy of six diagnostic tests for predicting perioperative cardiac risk in patients undergoing major vascular surgery.  Heart. 2003;  89 1327-1334
  • 19 Hoeks S, Flu W J, van Kuijk J P. et al . Cardiovascular risk assesment of the diabetic patient undergoing major noncardiac surgery.  Best Practice and Research Clinical Endocrinology and Metabolism. 2009;  23 361-373
  • 20 Mangano D T, Layug E L, Wallace A, Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group.  N Engl J Med. 1996;  335 1713-1720
  • 21 Poldermans D, Boersma E, Bax J J. et al . Bisoprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery.  Eur Heart J. 2001;  22 1353-1358
  • 22 Poldermans D, Boersma E, Bax J. et al . The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery.  N Engl J Med. 1999;  341 1789-1794
  • 23 Poldermans D, Boersma E, Bax J J. et al . Bisoprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery.  Eur Heart J. 2001;  22 1353-1358
  • 24 Yang H, Raymer K, Butler R. et al . The effects of perioperative beta-blockade: results of the Metoprolol after Vascular Surgery (MaVS) study, a randomized controlled trial.  Am Heart J. 2006;  152 983-990
  • 25 Devereaux P J, Yang H, Yusuf S. POISE Study Group . Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.  Lancet. 2008;  371 1839-1847
  • 26 Fleischmann K E, Beckmann J A, Buller C E. et al . Focused Update on Perioperative Beta Blockade.  JACC. 2009;  54 2102-2128
  • 27 Poldermans D, Bax J J, Kertai M D. et al . Statins are associated with a reduced incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery.  Circulation. 2003;  107 1848-1851
  • 28 Durazzo A E, Machado F S, Ikeoka D T. et al . Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial.  J Vasc Surg. 2004;  39 967-975; discussion 975 – 976
  • 29 Liu P Y, Liu Y W, Lin L J. et al . Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation.  Circulation. 2009;  119 131-138
  • 30 O’Neil-Callahan K, Katsimaglis G, Tepper M R. et al . Statins decrease perioperative cardiac complications in patients undergoing noncardiac vascular surgery: the Statins for Risk Reduction in Surgery (StaRRS) study.  J Am Coll Cardiol. 2005;  45 336-342
  • 31 Devereaux P J, Beattie W S, Choi P T. et al . How strong is the evidence for the use of perioperative (beta) blockers in noncardiac surgery? Systematic review and meta-analysis of randomised controlled trials.  BMJ. 2005;  331 313-321
  • 32 Merritt J C, Bhatt D L. The efficacy and safety of perioperative antiplatelet therapy.  J Thromb Thrombolysis. 2004;  17 21-27
  • 33 McQuaid K R, Laine L. Systematic Review and Meta-Analysis of Adverse Events of Low-Dose Aspirin and Clopidogrel in Randomized Controlled Trials.  Am J Med. 2006;  119 624-638
  • 34 Ferraris V A, Ferraris S P, Joseph O. et al . Aspirin and Postoperative Bleeding After Coronary Artery Bypass Grafting.  Ann Surg. 2002;  235 820-827
  • 35 Burger W, Chemnitius J M, Kneissl G D, Rücker G. Low-Dose Aspirin for Secondary Cardiovascular Prevention – Cardio vascular Risks After Its Perioperative Withdrawal Versus Bleeding Risks With Its Continuation – Review and Meta-Analysis.  J Intern Med. 2005;  257 399-414
  • 36 Yeager R A, Moneta G L, Edwards J M. et al . Reducing perioperative myocardial infarction following vascular surgery. The potential role of beta-blockade.  Arch Surg. 1995;  130 869-872; discussion 872 – 873
  • 37 CLASP Collaborative Group . A Randomized Trial of Low Dose Aspirin for the Prevention and Treatment of Pre-Eclampsia Among 9364 Pregnant Women.  Lancet. 1994;  343 619-629
  • 38 Horlocker T T. et al . Preoperative Antiplatelet Therapy Does Not Increase the Risk of Spinal Hematoma Associated With Regional Anesthesia.  Anesth Analg. 1995;  80 303-309
  • 39 Wijeysundera D N, Naik J S, Beattie W S. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis.  Am J Med. 2003;  114 742-752
  • 40 Wallace A W, Galindez D, Salahieh A. et al . Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery.  Anesthesiology. 2004;  101 284-293
  • 41 Gavras I, Manolis A J, Gavras H. The alpha2-adrenergic receptors in hypertension and heart failure: experimental and clinical studies.  J Hypertens. 2001;  19 2115-2124
  • 42 Stevens R D, Burri H, Tramer M R. Pharmacologic myocardial protection in patients undergoing noncardiac surgery: a quantitative systematic review.  Anesth Analg. 2003;  97 623-633
  • 43 Fleisher L A, Beckman J A, Brown K A. et al . ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery. A Report of the American College of Cardiology, American Heart Association Task Force on Practice Guidelines.  Circulation. 2007;  116 1971-1996
  • 44 Rodgers A, Walker N, Schug S. et al . Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials.  BMJ. 2000;  321 1493
  • 45 Rigg J R, Jamrozik K, Myles P S. et al . Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial.  Lancet. 2002;  359 1276-1282
  • 46 Sabatine M S, Morrow D A, Giugliano R P. et al . Association of hemoglobin levels with clinical outcomes in acute coronary syndromes.  Circulation. 2005;  111 2042-2049
  • 47 Van den Berghe G, Wouters P, Weekers F. et al . Intensive insulin therapy in the critically ill patients.  N Engl J Med. 2001;  345 1359-1367
  • 48 Alpert J S, Thygesen K, Antman E, Bassand J P. Myocardial infarction redefined – a consensus document of the Joint European Society of Cardiology, American College of Cardiology Committee for the redefinition of myocardial infarction.  J Am Coll Cardiol. 2000;  36 959-969
  • 49 Alpert J S. Defining myocardial infarction: Will the real myocardial infarction please stand up? (Editorial).  Am Heart J. 2003;  146 377-379
  • 50 Landesberg G, Mosseri M, Shatz V. et al . Cardiac troponin after major vascular surgery: the role of perioperative ischemia, preoperative thallium scanning, and coronary revascularization.  J Am Coll Cardiol. 2004;  44 569-575
  • 51 Kim L J, Martinez E A, Faraday N. et al . Cardiac troponin I predicts short-term mortality in vascular surgery patients.  Circulation. 2002;  106 2366-2371
  • 52 Le Manach Y, Perel A, Coriat P. et al . Early and delayed myocardial infarction after abdominal aortic surgery.  Anesthesiology. 2005;  102 885-891
  • 53 Filipovic M, Jeger R, Probst C. et al . Heart rate variability and cardiac troponin I are incremental and independent predictors of one-year all-cause mortality after major noncardiac surgery in patients at risk of coronary artery disease.  J Am Coll Cardiol. 2003;  42 1767-1776
  • 54 Landesberg G, Shatz V, Akopnik I. et al . Association of cardiac troponin, CK-MB, and postoperative myocardial ischemia with long-term survival after major vascular surgery.  J Am Coll Cardiol. 2003;  42 1547-1554
  • 55 Van de Werf F, Bax J, Betriu A. et al . The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology: Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation.  European Heart Journal. 2008;  29 2909-2945
  • 56 Kastrati A, Mehilli J, Neumann F J. et al . Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial.  JAMA. 2006;  295 1531-1538
  • 57 Bavry A A, Kumbhani D J, Rassi A N. et al . Benefit of early invasive therapy in acute coronary syndromes: a meta-analysis of contemporary randomized clinical trials.  J Am Coll Cardiol. 2006;  48 1319-1325
  • 58 Fox K A, Poole-Wilson P, Clayton T C. et al . 5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial.  Lancet. 2005;  366 914-920
  • 59 Cannon C P. Revascularisation for everyone?.  Eur Heart J. 2004;  25 1471-1472
  • 60 Hoenig M R, Doust J A, Aroney C N, Scott I A. Early invasive versus conservative strategies for unstable angina & non-ST-elevation myocardial infarction in the stent era.  Cochrane Database Syst Rev 3. 2006;  CD004815
  • 61 Bassand J P, Christian W, Hamm C W, Ardissino D. et al . The Task Force on the management of Non ST-segment elevation acute coronary syndroms of the European Society of Cardiology: Guidelines for the diagnosis and treatment of non-ST-elevation acute coronary syndroms.  European Heart Journal. 2007;  28 598-1660
  • 62 Theroux P, Ouimet H, McCans J. et al . Aspirin, heparin, or both to treat acute unstable angina.  N Engl J Med. 1988;  319 1105-1111
  • 63 Petersen J L, Mahaffey K W, Hasselblad V. et al . Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute coronary syndromes: a systematic overview.  JAMA. 2004;  292 89-96
  • 64 Ferguson J J, Califf R M, Antman E M. et al . Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial.  JAMA. 2004;  292 45-54
  • 65 Yusuf S, Mehta S R, Chrolavicius S. et al . Efficacy and safety of fondaparinux compared to enoxaparin in 20,078 patients with acute coronary syndromes without ST segment elevation. The OASIS (Organization to Assess Strategies in Acute Ischemic Syndromes)-5 Investigators.  N Engl J Med. 2006;  354 1464-1476
  • 66 Neumann F J, Kastrati A, Pogatsa-Murray G. et al . Evaluation of prolonged antithrombotic pretreatment („cooling-off” strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial.  JAMA. 2003;  290 1593-1599
  • 67 Stone G W, Bertrand M E, Moses J W. et al . Routine upstream initiation vs deferred selective use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: the ACUITY Timing Trial.  JAMA. 2007;  297 591-602
  • 68 Kontos M C, Shah R, Fritz L M. et al . Implication of different cardiac troponin I levels for clinical outcomes and prognosis of acute chest pain patients.  J Am Coll Cardiol. 2004;  43 958-965

Dr. med. Tilmann Schwab

Universitätsklinikum Freiburg
Abteilung Medizin III Kardiologie und Angiologie

Hugstetterstr. 55
79106 Freiburg

Phone: 0761/270-3493

Fax: 0761/270-3362

Email: tilmann.schwab@uniklinik-freiburg.de

>