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Semin Respir Crit Care Med 2010; 31(2): 189-207
DOI: 10.1055/s-0030-1249116
© Thieme Medical PublishersDOI: 10.1055/s-0030-1249116
Chronic Allograft Rejection: Epidemiology, Diagnosis, Pathogenesis, and Treatment
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
30. März 2010 (online)
ABSTRACT
Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders. Unfortunately, chronic lung allograft rejection, in the form of obliterative bronchiolitis and its clinical correlate bronchiolitis obliterans syndrome (BOS), continues to be highly prevalent and is the major limitation to long-term survival. The pathogenesis of BOS is complex and involves alloimmune and nonalloimmune pathways. The airway obstruction involved is classically progressive and unresponsive to treatment; however, the course is highly variable, and distinguishable phenotypes may exist. A better understanding of the risk factors and their relationship to the pathological mechanisms of chronic lung allograft rejection should lead to better pharmacological targets to prevent or treat this syndrome.
KEYWORDS
Lung transplantation - chronic rejection - bronchiolitis obliterans syndrome
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S. Samuel WeigtM.D.
The David Geffen School of Medicine at UCLA, Division of Pulmonary, Critical Care
Medicine, Allergy, and Clinical Immunology
10833 Le Conte Ave., 37-131 CHS, Los Angeles, CA 90095
eMail: sweigt@mednet.ucla.edu