Marrow Biopsy in Granulomatous Disorders: When and Why?

Marrow-biopsy to a rare kind of biopsies used in diagnostics of Granulomatous Disorders. 269 biopsies were done at our Center as routine method of analysis when diffusive pathology in lungs was detected.

Methods: 57 analytical investigations were done among 269 marrow biopsies in connection with Granulomatous: 28 biopsies (or 49,1%) were positive.

Pathology	Biopsies/Posit.	%
Tuberculosismiliary	38/19	33,3%
Sarcoidosis	17/8	14,1%
Histiocytosis X	2/1	1,7%
Total:	57/28	49,1%

We made marrow biopsies as last non-operational kind of biopsies in diagnostic algorithm of our investigations for patients with Granulomatous.

Conclusions: In our opinion, the usage of marrow biopsy in diagnostics of Granulomatous Disorders has typical evidence.

Marrow biopsies: When?

• Tuberculosis-miliary or Sarcoidosis generalisation?

• Metastases in marrow – or Granulomatous?

• Unknown aneamia in granulomatous inflammation.

• Sarcoidosis in marrow -indication by hormone therapy!

Why? Marrow biopsy is positive:

• simple techniques biopsy and absence of complication.

negative:

• rare Granulomatous Disordes localisation in marrow (˜ 5%);

• marrow biopsy is not much effectual (˜50% of all biopsies).