Int J Sports Med 2010; 31(7): 441-450
DOI: 10.1055/s-0030-1251994

© Georg Thieme Verlag KG Stuttgart · New York

Effects of Resistance Training on Cytokines

B. F. de Salles1 , R. Simão2 , S. J. Fleck3 , I. Dias1 , L. G. Kraemer-Aguiar1 , E. Bouskela1
  • 1Universidade do Estado do Rio de Janeiro, Physiological Sciences Department, Rio de Janeiro, Brazil
  • 2Universidade Federal do Rio de Janeiro, School of Physical Education and Sports, Rio de Janeiro, Brazil
  • 3Colorado College, Sport Science Department, Colorado Springs, United States
Further Information

Publication History

accepted after revision February 25, 2010

Publication Date:
29 April 2010 (online)


It is speculated that exercise training decreases resting levels of tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP); reduces body mass and leptin (LP); and increases adiponectin (AD) and insulin sensitivity. This systematic review analyzed the effectiveness of resistance training (RT) longitudinal clinical studies on AD, LP, CRP and TNF-α. Seventeen studies were included and the majority of randomized controlled trials support that RT produces increases in AD, and decreases in both LP and CRP. Greater responses in AD and LP were evident in overweight and obese individuals; while RT appeared to be effective in reducing CRP in obese individuals, and older adults. Additionally, women may be more responsive to RT effects on AD, LP and CRP. Training duration and intensity may affect the response of AD and CRP with greater responses shown with 16 weeks or more of training and/or with intensities greater than 80% of one repetition maximum. No response to RT of TNF-α levels was apparent. Although based on a limited number of studies, some of which are uncontrolled non-randomized in design, our review suggests some positive effects of RT programs on cytokine levels, but specifics of the responses in different populations need further elucidation.



Prof. Belmiro Freitas de Salles

Universidade do Estado do

Rio de Janeiro

Physiological Sciences


Laboratory for Clinical and

Experimental Research in

Vascular Biology (BioVasc)

Biomedical Center

Universidade do Estado do

Rio de Janeiro

20550-013 Rio de Janeiro


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