Facile and Highly Efficient
N-Formylation of Amines Using a Catalytic Amount of Iodine under
Solvent-Free Conditions

Joong-Gon Kim; Doo Ok Jang

doi:10.1055/s-0030-1258518

LETTER

Facile and Highly Efficient N-Formylation of Amines Using a Catalytic Amount of Iodine under Solvent-Free Conditions

Joong-Gon Kim^a, Doo Ok Jang*^b
^a Biotechnology Division, Hanwha Chemical R&D Center, Daejeon 305-345, South Korea
^b Department of Chemistry, Yonsei University, Wonju 220-710, South Korea
Fax: +82(33)7602182; e-Mail: dojang@yonsei.ac.kr;

Abstract

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Abstract

We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and α-amino acid esters without epimerization.

Key words

amine - N-formylation - formic acid - iodine catalysis - solvent-free

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