Facile Synthesis of Highly Substituted Iminocyclopentenes: A Novel Isocyanide-Based Three-Component Condensation Reaction

Abstract

The reaction of alkoxymethylenemalononitrile with dialkyl acetylenedicarboxylates (DAAD) and cyclohexylisocyanide results in a three-component condensation reaction in which the alkoxymethylenemalononitrile group acts as a dipolarophile, producing highly functionalized iminocyclopentenes under mild conditions in high yields.

alkoxymethylenemalononitrile - dialkyl acetylenedicarboxylates - isocyanides - iminocyclopentenes

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