Horm Metab Res 2011; 43(1): 17-21
DOI: 10.1055/s-0030-1265130
Original Basic

© Georg Thieme Verlag KG Stuttgart · New York

Regulation of FTO and FTM Expression During Human Preadipocyte Differentiation

D. Tews1 , P. Fischer-Posovszky1 , M. Wabitsch1
  • 1Division of Pediatric Endocrinology and Diabetes, Endocrine Research Laboratory, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany
Further Information

Publication History

received 22.06.2010

accepted 10.08.2010

Publication Date:
23 September 2010 (eFirst)

Abstract

In genome-wide association studies (GWAS), polymorphisms in the first intron of FTO were shown to be associated with body fat mass. However, the functional properties of FTO and its nearby gene FTM are largely unknown. We examined the expression of these genes in subcutaneous adipose tissue and in isolated preadipocytes of lean and obese women. In in vitro differentiated primary human preadipocytes and in SGBS preadipocytes we found a decline in FTO and FTM expression during adipogenic differentiation. When investigating the hormonal regulation of FTO and FTM in adipocytes, insulin was identified as a key factor regulating FTM expression indicating a potential role of FTM in insulin regulated adipocyte metabolism.

References

Correspondence

Prof. Dr. M. Wabitsch

Division of Pediatric Endocrinology

and Diabetes

Department of Pediatrics and

Adolescent Medicine

University of Ulm

Eythstraße 24

89075 Ulm

Germany

Phone: +49/731/500 57401

Fax: +49/731/500 57407

Email: martin.wabitsch@uniklinik-ulm.de