Background: High blood pressure (BP) is an established risk factor for cardiovascular disease.
However, BP measurement conditions in epidemiological studies vary, leading to different
estimates of hypertension frequencies. The aim of the study was to evaluate the dependence
of BP estimates on different measurement conditions. Methods: This analysis uses data of 1778 participants (45–83 years) of the baseline investigation
of the CARLA study. BP measurements using oscillometric devices included three sitting
measurements at the left arm, one simultaneous supine measurement at both arms, and
three supine measurements at the arm with the higher BP. We calculated means and 95%
confidence intervals of differences between measurements and used linear regression
to evaluate determinants of BP differences. Furthermore, we assessed the dependence
of the prevalence of high BP (≥140/90mmHg) on the choice of BP measures used. Results: Mean diastolic BP (DPB) was slightly higher on left arm (mean DBP difference=0.98mmHg)
whereas no differences were observed in systolic BP (SBP). Sitting SBP and DBP were
higher than the corresponding supine BP (mean SBP difference=4.02mmHg; DBP=2.97mmHg).
The BP difference by body position depends strongly on age and BP. Mean sitting and
supine BP declined from first to second and second to third measurement by SBP=1.64
(sitting)/1.64 (supine) and 1.29/0.66 and DBP=0.51/0.94 and 0.21/0.33mmHg, respectively.
The degree of BP decline depends on age, BP and BMI. The highest prevalence of high
BP was found by using the first sitting measurement (63.60%), the lowest by using
the third supine measurement (47.11%). Conclusion: Measured BP strongly depends on posture, number and combination of subsequent BP
readings. BP measurements should only be compared between studies applying equal measurements
conditions. The first BP measurement should not be used to define hypertension since
it overestimates mean BP.