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Horm Metab Res 2010; 42(13): 912-917
DOI: 10.1055/s-0030-1268457
Review

© Georg Thieme Verlag KG Stuttgart · New York

Endocrine Organs Under the Control of the Immune System: Potential Implications for Cellular Therapies

B. Jacobs1 , 2 , [*] , C. Papewalis1 , [*] , M. Ehlers1 , M. Schott1
  • 1Endocrine Cancer Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany
  • 2Department of Internal Medicine 5, Hemotology and Internal Oncology, University Hospital Erlangen, Erlangen, Germany
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Publikationsverlauf

received 11.10.2010

accepted 28.10.2010

Publikationsdatum:
03. Dezember 2010 (online)

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Abstract

Within the last couple of years much knowledge has been gained in understanding the immune interactions in endocrine diseases including endocrine malignancies and autoimmune diseases. The major players within the innate immune system represent NK cells. This review describes that these cells directly lyse tumor cells and promote the activity of other cells of the immune system, including dendritic cells (DCs), macrophages, Th1 cells, and cytotoxic T-lymphocytes (CTLs). NK cells may also be involved in the initiation of autoimmunity as they may accumulate in target organs of certain autoimmune diseases. On the other hand, there are cells of the adaptive immune system including antigen-presenting DCs and T cells with helper and effector function, which are responsible for a directed immune response. Within this review, we present an overview on the role of all these cell populations in endocrine disease and the potential use of such cells for immunotherapy in different endocrine diseases and refer to experimental settings as well as clinical studies.

Key words

dendritic cells (DCs) - natural killer (NK) cells - cytotoxic T cells (CTLs) - adoptive cell therapy - autoimmune thyroiditis (AIT) - diabetes - graft-versus-host disease (GVHD)

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1 These authors contributed equally to the manuscript.

Correspondence

Dr. M.Schott 

Endocrine Cancer Center

Department of Endocrinology,

Diabetes and Rheumatology

University Hospital D ü sseldorf

Moorenstr. 5

40225 Düsseldorf

Germany

Telefon: 49/211/8117 810

Fax: 49/211/8117 860

eMail: matthias.schott@med.uni-duesseldorf.de