Horm Metab Res 2011; 43(1): 72-74
DOI: 10.1055/s-0030-1268485
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Low Vitamin D Levels in Northern American Adults with the Metabolic Syndrome

S. Devaraj1 , G. Jialal1 , T. Cook1 , D. Siegel1 , 2 , I. Jialal1 , 2
  • 1Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA, USA
  • 2Veterans Affairs Medical Center, Mather, CA, USA
Further Information

Publication History

received 17.09.2010

accepted 03.11.2010

Publication Date:
25 November 2010 (online)


Metabolic syndrome (MetS), is a constellation of cardiometabolic disease risk factors, that affects 1 in 3 US adults and predisposes to increased risks for both diabetes and cardiovascular disease. While epidemiological studies show low vitamin D [(25(OH)D] levels in MetS, there is sparse data on vitamin D status in MetS patients in North America. Thus, the aim of our study was to examine plasma vitamin D concentration among adults with MetS in Northern California (sunny climate), but without diabetes or cardiovascular disease. 25(OH)D levels were significantly decreased in MetS compared to controls. 8 % of controls and 30% of MetS North American adult subjects were deficient in 25(OH)D (<20 ng/ml; p=0.0236, Controls vs. MetS). There were no significant differences between the groups with respect to blood sampling in winter and summer months, total calcium and phosphate, and creatinine levels. Vitamin D levels were significantly inversely correlated with fasting glucose (r=−0.29, p=0.04) and HOMA (r=−0.34, p=0.04). Future studies of vitamin D supplementation in these subjects on subsequent risk of diabetes will prove instructive with respect to potential health claims in these high risk patients with MetS.


  • 1 Holick MF. N Engl J Med. 2007;  357 266-281
  • 2 Martini LA, Wood R. Nutr Rev. 2006;  64 479-486
  • 3 Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr. Circulation. 2009;  120 1640-1645
  • 4 Chiu KC, Chu A, Go VL, Saad MF. Am J Clin Nutr. 2004;  79 820-825
  • 5 Ford ES, Ajani UA, McGuire LC, Liu S. Diabetes Care. 2005;  28 1228-1230
  • 6 Reis JP, von Muhlen D, Miller ER. Eur J Endocrinol. 2008;  159 41-48
  • 7 Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Diabetes. 2008;  57 2619-2625
  • 8 Reis JP, von Muhlen D, Kritz-Silverstein D, Wingard DL, Barrett-Connor E. Diabetes Care. 2007;  30 1549-1555
  • 9 Grundy SM, Cleeman JI, Daniels SR, Donato K, Eckel RH, Franklin BA, Gordon DJ, Kraus RM, Savage PJ, Smith  SC, Spertus JA, Costa F. Circulation. 2005;  112 2735-2752
  • 10 Liu S, Song Y, Ford ES, Manson JE, Buring JE, Ridker PM. Diabetes Care. 2005;  28 2926-2932


I. Jialal, MD, PhD 


Laboratory for Atherosclerosis

and Metabolic Research

UC Davis Medical Center

4635, Second Ave

95817 Sacramento CA


Phone: +1/916/7346 592

Fax: +1/916/7346 593

Email: ishwarlal.jialal@ucdmc.ucdavis.edu