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DOI: 10.1055/s-0030-1269853
© Georg Thieme Verlag KG Stuttgart · New York
Thyroid Hormones Affect Plasma Ghrelin and Obestatin Levels
Publication History
received 21.06.2010
accepted 10.11.2010
Publication Date:
16 December 2010 (online)

Abstract
Using radioimmunoassay, the effects of thyroid hormones on plasma total ghrelin (Gh) and obestatin (Ob) concentrations were evaluated in thyrotoxic patients with an excess of thyroid hormones and in hypothyroid patients lacking endogenous thyroid hormones. 24 patients with thyrotoxicosis, 25 hypothyroid patents after total thyreoidectomy performed due to thyroid cancer, and 17 control subjects were examined. Compared with the controls, the ghrelin and obestatin were elevated in hypothyroidism, while they were decreased in thyrotoxicosis. The plasma Gh and Ob levels differ depending on the thyroid function. In thyroid hormones deficiency, plasma Gh and Ob are increased, while in patients with excess of thyroid hormones, the levels of both Gh and Ob are definitely lower. Gh/Ob ratio is higher in hypothyroidism than in control subjects and thyrotoxic patients.
Key words
thyroid hormones - ghrelin - obestatin
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Correspondence
J. Kosowicz
Department of Endocrinology,
Metabolism and Internal
Diseases
Poznan University of Medical
Sciences
Przybyszewskiego Street 49
60-355 Poznan
Poland
Phone: +48/61/8691330
Fax: +48/61/8691682
Email: endosk2@umed.poznan.pl