Int J Sports Med 2011; 32(5): 319-326
DOI: 10.1055/s-0030-1269892
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Training, Leptin Receptors and SOCS3 in Human Muscle

H. Olmedillas1 , B. Guerra1 , A. Guadalupe-Grau1 , A. Santana1 , 2 , 3 , T. Fuentes1 , C. Dorado1 , J. A. Serrano-Sanchez1 , J. A. L. Calbet1
  • 1University of Las Palmas de Gran Canaria, Department of Physical Education, Las Palmas de Gran Canaria, Spain
  • 2Genetic Unit, Childhood Hospital-Materno Infantil de Las Palmas, Avenida Marítima, del Sur s/n, Las Palmas de Gran Canaria, Spain
  • 3Research Unit, Hospital de Gran Canaria Doctor Negrı'n, Bco Ballena s/n, Las Palmas de Gran Canaria, Spain
Further Information

Publication History

accepted after revision November 12, 2010

Publication Date:
05 May 2011 (online)


Endurance exercise induces suppressor of cytokine signaling 3 (SOCS3) mRNA expression in rodent skeletal muscle and endurance training overimposed on strength training blunts the hypertrophic response to strength training by an unknown mechanism. The aim of this study was to determine the effects of a concurrent strength and endurance training on fat mass, serum leptin concentration, muscle morphology, and muscle vastus lateralis leptin receptors (OB-Rb) and SOCS3 protein expression. 16 healthy young men were assigned to a control (C; n=7), and to a 12-week weightlifting (3 sessions/week)+endurance training program (T; n=9) group. Training enhanced maximal dynamic strength in lower and upper body exercises (18–54%), reduced fat mass by 1.8 kg and serum leptin concentration per kg of fat mass, and elicited muscle hypertrophy of type 2 (+18.5%, P<0.05) but not of type 1 muscle fibres (+4.6%, P=NS). No significant changes were observed in either OB-Rb or SOCS3 protein expression with training. In conclusion, concurrent strength and endurance training reduces fat mass and serum leptin and the ratio leptin/fat mass without significant effects on vastus lateralis OB-Rb protein expression. Training does not increase the basal expression of SOCS3 protein in humans.


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Prof. Jose A. L. CalbetMD, PhD 

University of Las Palmas de

Gran Canaria

Physical Education

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