Horm Metab Res 2011; 43(7): 505-512
DOI: 10.1055/s-0031-1275704
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Pioglitazone Compared to Glibenclamide on Lipid Profile and Inflammation Markers in Type 2 Diabetic Patients During an Oral Fat Load

G. Derosa1 , A. F. G. Cicero2 , E. Fogari1 , A. D’Angelo1 , L. Bianchi1 , P. Maffioli1
  • 1Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
  • 2“G. Descovich” Atherosclerosis Study Center, Department of Internal Medicine, Aging and Kidney Diseases, University of Bologna, Bologna, Italy
Further Information

Publication History

received 07.02.2011

accepted 22.03.2011

Publication Date:
17 May 2011 (online)

Abstract

The aim of the study was to evaluate the effect of pioglitazone and glibenclamide on lipid profile and inflammatory parameters during an oral fat load (OFL). A total of 201 type 2 diabetic patients on treatment with metformin were enrolled in the study; pioglitazone was titrated till 45 mg/day and glibenclamide till 15 mg/day, in association with metformin, respectively. The patients underwent an OFL at baseline and after 12 months. The OFL was given between 08.00 and 09.00 h after a 12-h fast. Blood samples were drawn before and 3, 6, 9, and 12 h after the OFL. We evaluated glycemic-metabolic parameters [glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment (Homa) index], total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (Tgs), interleukin-6 (IL-6), high sensitivity C-reactive protein (Hs-CRP), tumor necrosis factor-α (TNF-α), and adiponectin (ADN). Pioglitazone was better than glibenclamide in decreasing HbA1c, FPG, FPI, lipid profile, and in improving inflammatory parameters such as Hs-CRP, and ADN. Comparing the OFL performed at baseline, and the OFL performed at the end of the study, pioglitazone, but not glibenclamide, improved all post-OFL peaks for all parameters. Comparing the 12 months OFL in the group treated with pioglitazone and in the group treated with glibenclamide, the values recorded with pioglitazone were significantly better than the ones obtained with glibenclamide. We can conclude that pioglitazone was better than glibenclamide in mitigating the variations of lipid components and inflammation parameters in type 2 diabetic patients.

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Correspondence

G. DerosaMD, PhD 

Department of Internal

Medicine and Therapeutics

University of Pavia

P. le C. Golgi 2

27100 Pavia

Italy

Phone: +39/0382/5262 17

Fax: +39/0382/5262 59

Email: giuseppe.derosa@unipv.it

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