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Skull Base Rep 2011; 1(2): 095-098
DOI: 10.1055/s-0031-1276723
© Thieme Medical Publishers

Hepatoid Adenocarcinoma of the Anterior Skull Base: A Case Report

Rebecca Zener1 , Olga Gologan2 , Noah Sands1 , Anthony G. Zeitouni1
  • 1Department of Otolaryngology–Head and Neck Surgery, McGill University Health Center, Montreal, Quebec, Canada
  • 2Department of Pathology, McGill University Health Center, Montreal, Quebec, Canada
Further Information

Publication History

Publication Date:
11 April 2011 (online)

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ABSTRACT

We report the first case of hepatoid adenocarcinoma of the skull base, as well as the first reported case in the head and neck region. Hepatoid adenocarcinoma is a rare, aggressive, extrahepatic malignancy with a distinct morphological similarity to hepatocellular carcinoma, in the absence of primary hepatic disease. A 45-year-old man presented with sinus headaches and retro-orbital pain and was found to have a nasopharyngeal mass on endoscopy and a large, destructive sinonasal mass extending intracranially on imaging. Histo- and cytopathological features were similar to hepatocellular carcinoma, and the cells were immunoreactive for α-fetoprotein, epithelial membrane antigen, periodic acid-Schiff, cytokeratin (CK)8/18, CK19, and S100.

KEYWORDS

Hepatoid adenocarcinoma - skull base tumors - AFP - sinonasal tumors

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Anthony G ZeitouniM.D. M.Sc. 

Royal Victoria Hospital, 687 Pine Avenue West

E4.45, Montreal, Quebec, Canada, H3A 1A1

Email: anthony.zeitouni@mcgill.ca

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