Int J Angiol 2007; 16(2): 50-52
DOI: 10.1055/s-0031-1278247
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Earliest time of change in QT dispersion after stenting in patients with single vessel coronary artery disease

Gholam Reza Rezaian1 , Hooman Shariati Ghadicolay2 , Mohammad Bagher Sharif Kazemi3 , Mahmood Zamirian4 , Kamran Aghasadeghi5 , Shahed Rezaian1
  • 1Department of Medicine (Cardiology), Shiraz University of Medical Sciences, Shiraz;
  • 2Kazeroon Hospital, Kazeroon;
  • 3Alzahra Hospital Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Further Information

Publication History

Publication Date:
27 April 2011 (online)


Dispersion of the QT interval (QTd) is a measure of inhomogeneity of ventricular repolarization, and its prolongation may provide a suitable substrate for life-threatening ventricular arrhythmias. The present study was performed to determine the onset time of change in the corrected QT (QTc) interval and QTd in patients with stable angina and single vessel coronary artery disease. Electrocardiograms of 60 patients with successful stenting, obtained 1 h before and 1 h, 6 h, 12 h and 24 h after the procedure were analyzed. The QTc interval, QTc maximum, QTc minimum and QTd were measured. All electrocardiograms were scanned, and then underwent computer-based analysis. There was a significant reduction in the mean QTc interval as early as 12 h after the procedure (from 474±41 ms to 460±31 ms; P<0.001), which persisted to the 24 h follow-up. This was associated with a significant reduction in mean QT maximum (from 496±31 ms to 418±66 ms; Pt;0.001) and a significant prolongation in mean QT minimum (from 403±21 ms to 444±12 ms; P<0.001) at the same time intervals. Therefore, successful stenting of coronary arteries in patients with single vessel coronary artery disease and stable angina decreases QTd as early as 12 h after the procedure. This phenomenon may be the result of improved regional myocardial circulation, and reduced ischemia. A persistently low QTd in the following months may therefore have prognostic significance, and can be used as a noninvasive marker of stent patency. Further studies are necessary to define the clinical applicability of QTd in the assessment of long-term stent patency in such patients.