Die Rolle der Betazelle im Diabetes mellitus

Schlüsselwörter

Betazellen des Pankreas - Typ-1-Diabetes - Typ-2-Diabetes - Therapie

Keywords

beta cells - diabetes type 1 - diabetes type 2 - treatment

Literatur

• 1 Bluestone J A, Auchincloss H, Nepom G T. et al . The Immune Tolerance Network at 10 years: tolerance research at the bedside.  Nat Rev Immunol. 2010;  10 797-803
• 2 Cnop M, Welsh N, Jonas J C. et al . Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.  Diabetes. 2005;  54 (Suppl 2) S97-107
• 3 Eisenbarth G S. Type 1 diabetes. Molecular, cellular and clinical immunology. Book. Online Edition version 3.0 ed;. http://www.barbaradaviscenter.org/ 2010
• 4 Eizirik D L, Colli M L, Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.  Nature reviews. 2009;  5 219-226
• 5 Elsner M, Gehrmann W, Lenzen S. Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells.  Diabetes. 2011;  60 200-218
• 6 Gehrmann W, Elsner M, Lenzen S. Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic beta-cells.  Diabetes, obesity & metabolism. 2010;  12 (Suppl 2) 149-158
• 7 Gurgul E, Lortz S, Tiedge M, Jörns A, Lenzen S. Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.  Diabetes. 2004;  53 2271-2280
• 8 Jörns A, Günther A, Hedrich H J. et al . Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.  Diabetes. 2005;  54 2041-2052
• 9 Leahy J L, Hirsch I B, Peterson K A, Schneider D. Targeting beta-cell function early in the course of therapy for type 2 diabetes mellitus.  The Journal of clinical endocrinology and metabolism. 2010;  95 4206-4216
• 10 Lenzen S. Oxidative stress: the vulnerable beta-cell.  Biochemical Society transactions. 2008;  36 343-347
• 11 Rahier J, Guiot Y, Goebbels R M, Sempoux C, Henquin J C. Pancreatic beta-cell mass in European subjects with type 2 diabetes.  Diabetes, obesity & metabolism. 2008;  10 (Suppl 4) 32-42
• 12 Schloot N C. Immunintervention zum Betazellerhalt bei Typ-1-Diabetes.  Dtsch Med Wochenschr. 2010;  135 915-921
• 13 Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.  Diabetes. 1997;  46 1733-1742
• 14 Waldhäusl W, Lenzen S S. Kapitel 14. Kohlenhydratstoffwechsel. In: Schwarz S, Förster O, Peterlik M, Schauenstein K, Wick G, ed. Pathophysiologie – Molekulare, zelluläre, systemische Grundlagen von Erkrankungen.. Wien: Wilhelm Maudrich Verlag; 2007