Die enterische Glia – Ein Teil des Crohn Puzzles?

Zusammenfassung

Die enterische Glia hat eine überlebensnotwendige Funktion in der Regulation der Darmhomöostase. Mit dem Verlust dieser Zellentität kommt es zu einem Zusammenbruch der Darmepithelbarriere gefolgt von einer tödlich endenden transmuralen Entzündung des Darmes. Eine gestörte mukosale Barrierefunktion beim Morbus Crohn ist gut belegt. Die endgültige Rolle der enterischen Glia in der Entstehung und im Krankheitsverlauf des Morbus Crohn ist nicht geklärt. Unter Berücksichtigung eines möglichen neuen Therapieziels des Morbus Crohns, der sog. „mukosalen Heilung“, ist es erforderlich, die enterische Glia als eine tragende Säule für eine intakte Darmepithelgrenze unter therapeutischen Gesichtspunkten weiter zu untersuchen.

Abstract

Enteric glia cells are essential for the mucosal integrity of the gut. A leakage of the epithelial barrier is postulated in Crohn’s disease. The role of enteric glia cells in the onset and progress of Crohn’s disease is not clear yet. A new approach in the therapy of Crohn’s disease is to target “mucosal healing”. Since enteric glia cells are an important source of factors that regulate the epithelial barrier function, further research and discussion about this cell entity under therapeutic aspects is urgently necessary.

Schlüsselwörter

Morbus Crohn - enterische Glia - Darmhomöostase

Key words

Crohn’s disease - enteric glia - mucosal integrity

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