PDF herunterladen
Ultraschall Med 2012; 33(2): 135-140
DOI: 10.1055/s-0031-1281936
Review
© Georg Thieme Verlag KG Stuttgart · New York

Intravenous Application of Second-Generation Ultrasound Contrast Agents in Children: A Review of the Literature

Intravenöse Gabe von Ultraschallkontrastmitteln der zweiten Generation an Kinder: Eine Literaturübersicht
M. Piskunowicz
1   Radiology, Medical University of Gdansk
,
W. Kosiak
2   Department of Paediatric, Haematology, Oncology and Endocrinology, Medical University of Gdansk
,
T. Batko
2   Department of Paediatric, Haematology, Oncology and Endocrinology, Medical University of Gdansk
› Institutsangaben
Weitere Informationen

Publikationsverlauf

15. März 2011

10. Oktober 2011

Publikationsdatum:
09. Dezember 2011 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Abstract

CEUS examinations using second-generation ultrasound contrast agents (UCA) are conducted in children, despite not being registered for individuals less than 18 years of age. We searched the Medline® database through Pubmed® and Scopus database, in order to find articles in which UCA were administered intravenously in patients under the age of 18. We analyzed in detail 9 papers (7 case reports, 2 original research studies), describing the examinations with intravenous administration of the UCA in children, and 23 original papers, in which the study group included at least one individual under the age of 18. Neither of the analyzed studies included any reports of adverse effects after UCA administration.

Zusammenfassung

Trotz fehlender Zulassung bei Personen unter 18 Jahren werden CEUS-Untersuchungen mit Kontrastmitteln der zweiten Generation (UCA) an Kindern durchgeführt. Wir durchsuchten die Datenbanken von Medline®, Pubmed® und Scopus, um Publikationen zu finden, bei denen UCAs intravenös an Patienten unter 18 verabreicht wurden. Im Detail untersuchten wir neun Arbeiten (7 Fallberichte, 2 Orginal-Forschungsstudien), die Untersuchungen an Kindern unter intravenöser Gabe von UCA beschreiben, sowie 23 Originalarbeiten, in denen die Studiengruppe mindestens eine Person unter 18 Jahren beinhaltete. In keiner der untersuchten Studien gab es irgendwelche Berichte über Nebenwirkungen nach UCA-Gabe.

Key words

ultrasound - contrast agents - children
 

  • References

  • 1 Strobel D, Seitz K, Blank W et al. Tumor-specific vascularization pattern of liver metastasis, hepatocellular carcinoma, hemangioma and focal nodular hyperplasia in the differential diagnosis of 1,349 liver lesions in contrast-enhanced ultrasound (CEUS). Ultraschall in Med 2009; 30: 376-382
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 2 Seitz K, Bernatik T, Strobel D et al. Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI – a prospective comparison in 269 patients.. Ultraschall in Med 2010; 31: 492-499
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 3 Haynes RB, McKibbon KA, Wilczynski NL et al. Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ 2005; 330: 1179-1184
    CrossrefPubMedGoogle Scholar
  • 4 Montori VM, Wilczynski NL, Morgan D et al. Optimal search strategies for retrieving systematic reviews from Medline: analytical survey. BMJ 2005 2005; 330: 68-73
    PubMedGoogle Scholar
  • 5 Oldenburg A, Hohmann J, Skrok J et al. Imaging of paediatric splenic injury with contrast-enhanced ultrasonography. Pediatr Radiol 2004; 34: 351-354
    CrossrefPubMedGoogle Scholar
  • 6 Valentino M, Galloni SS, Rimondi MR et al. Contrast-enhanced ultrasound in non-operative management of pancreatic injury in childhood. Pediatr Radiol 2006; 36: 558-560
    CrossrefPubMedGoogle Scholar
  • 7 Thorelius L. Emergency real-time contrast-enhanced ultrasonography for detection of solid organ injuries. Eur Radiol 2007; 17: F107-F111
    CrossrefPubMedGoogle Scholar
  • 8 D’Onofrio M, Martone E, Faccioli N et al. Focal liver lesions: sinusoidal phase of CEUS. Abdom Imaging 2006; 31: 529-36
    CrossrefPubMedGoogle Scholar
  • 9 Mandry D, Bressenot A, Galloy MA et al. Contrast-enhanced ultrasound in fibro-lamellar hepatocellular carcinoma: a case report. Ultraschall in Med 2007; 28: 547-552
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 10 Luo XL, Liu D, Yang JJ et al. Primary gastrointestinal stromal tumor of the liver: a case report. World J Gastroenterol 2009; 15: 3704-3707
    CrossrefPubMedGoogle Scholar
  • 11 Svensson JF, Larsson A, Uusijärvi J et al. Oophoropexy, hyperbaric oxygen therapy, and contrast-enhanced ultrasound after asynchronous bilateral ovarian torsion. J Pediatr Surg 2008; 43: 1380-1384
    CrossrefPubMedGoogle Scholar
  • 12 Valentino M, Serra C, Pavlica P et al. Blunt abdominal trauma: diagnostic performance of contrast-enhanced US in children – initial experience. Radiology 2008; 246: 903-909
    CrossrefPubMedGoogle Scholar
  • 13 Bonini G, Pezzotta G, Morzenti C et al. Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound 2007; 10: 99-106
    CrossrefPubMedGoogle Scholar
  • 14 Stang A, Keles H, Hentschke S et al. Differentiation of benign from malignant focal splenic lesions using sulfur hexafluoride-filled microbubble contrast-enhanced pulse-inversion sonography. AJR Am J Roentgenol 2009; 193: 709-721
    CrossrefPubMedGoogle Scholar
  • 15 Wang WP, Wu Y, Luo Y et al. Clinical value of contrast-enhanced ultrasonography in the characterization of focal liver lesions: a prospective multicenter trial. Hepatobiliary Pancreat Dis Int 2009; 8: 370-376
    PubMedGoogle Scholar
  • 16 Ungermann L, Eliás P, Zizka J et al. Focal nodular hyperplasia: spoke-wheel arterial pattern and other signs on dynamic contrast-enhanced ultrasonography. Eur J Radiol 2007; 63: 290-294
    CrossrefPubMedGoogle Scholar
  • 17 Soye JA, Mullan CP, Porter S et al. The use of contrast-enhanced ultrasound in the characterisation of focal liver lesions. Ulster Med J 2007; 76: 22-25
    PubMedGoogle Scholar
  • 18 Wu W, Chen MH, Yin SS et al. The role of contrast-enhanced sonography of focal liver lesions before percutaneous biopsy. AJR Am J Roentgenol 2006; 187: 752-761
    CrossrefPubMedGoogle Scholar
  • 19 Görg C, Graef C, Bert T. Contrast-enhanced sonography for differential diagnosis of an inhomogeneous spleen of unknown cause in patients with pain in the left upper quadrant. J Ultrasound Med 2006; 25: 729-734
    PubMedGoogle Scholar
  • 20 Manetta R, Pistoia ML, Bultrini C et al. Ultrasound enhanced with sulphur-hexafluoride-filled microbubbles agent (SonoVue) in the follow-up of mild liver and spleen trauma. Radiol Med 2009; 114: 771-779
    CrossrefPubMedGoogle Scholar
  • 21 Catalano O, Aiani L, Barozzi L et al. CEUS in abdominal trauma: multi-center study. Abdom Imaging 2009; 34: 225-234
    CrossrefPubMedGoogle Scholar
  • 22 Valentino M, Serra C, Zironi G et al. Blunt abdominal trauma: emergency contrast-enhanced sonography for detection of solid organ injuries. AJR Am J Roentgenol 2006; 186: 1361-1367
    CrossrefPubMedGoogle Scholar
  • 23 Catalano O, Sandomenico F, Raso MM et al. Real-time, contrast-enhanced sonography: a new tool for detecting active bleeding. J Trauma 2005; 59: 933-939
    CrossrefPubMedGoogle Scholar
  • 24 Catalano O, Lobianco R, Sandomenico F et al. Real-time, contrast-enhanced sonographic imaging in emergency radiology. Radiol Med 2004; 108: 454-469
    PubMedGoogle Scholar
  • 25 Miele V, Buffa V, Stasolla A et al. Contrast enhanced ultrasound with second generation contrast agent in traumatic liver lesions. Radiol Med 2004; 108: 82-91
    PubMedGoogle Scholar
  • 26 Catalano O, Lobianco R, Sandomenico F et al. Real-time contrast-enhanced ultrasound of the spleen: examination technique and preliminary clinical experience. Radiol Med 2003; 106: 338-356
    PubMedGoogle Scholar
  • 27 Bhayana D, Kim TK, Jang HJ et al. Hypervascular liver masses on contrast-enhanced ultrasound: the importance of washout. AJR Am J Roentgenol 2010; 194: 977-983
    CrossrefPubMedGoogle Scholar
  • 28 Lanka B, Jang HJ, Kim TK et al. Impact of contrast-enhanced ultrasonography in a tertiary clinical practice. J Ultrasound Med 2007; 26: 1703-1714
    PubMedGoogle Scholar
  • 29 Heppner P, Ellegala DB, Durieux M et al. Contrast ultrasonographic assessment of cerebral perfusion in patients undergoing decompressive craniectomy for traumatic brain injury. J Neurosurg 2006; 104: 738-745
    CrossrefPubMedGoogle Scholar
  • 30 Malagò R, D’Onofrio M, Zamboni GA et al. Contrast-enhanced sonography of nonfunctioning pancreatic neuroendocrine tumors. AJR Am J Roentgenol 2009; 192: 424-430
    CrossrefPubMedGoogle Scholar
  • 31 Yang W, Chen MH, Yan K et al. Differential diagnosis of non-functional islet cell tumor and pancreatic carcinoma with sonography. Eur J Radiol 2007; 62: 342-351
    CrossrefPubMedGoogle Scholar
  • 32 Görg C, Egbring J, Bert T. Contrast-enhanced ultrasound of epiploic appendagitis. Ultraschall in Med 2009; 30: 163-167
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 33 De Pascale A, Garofalo G, Perna M et al. Contrast-enhanced ultrasonography in Crohn’s disease. Radiol Med 2006; 111: 539-550
    CrossrefPubMedGoogle Scholar
  • 34 He W, Jiang XQ, Wang S et al. Intraoperative contrast-enhanced ultrasound for brain tumors. Clin Imaging 2008; 32: 419-424
    CrossrefPubMedGoogle Scholar
  • 35 Wang Y, Wang Y, Wang Y et al. Intraoperative real-time contrast-enhanced ultrasound angiography: a new adjunct in the surgical treatment of arteriovenous malformations. J Neurosurg 2007; 107: 959-964
    CrossrefPubMedGoogle Scholar
  • 36 Prantl L, Pfister K, Kubale R et al. Value of high resolution ultrasound and contrast enhanced US pulse inversion imaging for the evaluation of the vascular integrity of free-flap grafts. Clin Hemorheol Microcirc 2007; 36: 203-216
    PubMedGoogle Scholar
  • 37 Liver mass – focal nudular hyperplasia (FNH). Avaiable at: http://www.radiologyforum.net/?id=20081216172615&lang=en&diagnosis=Liver-mass–focal-nudular-hyperplasia-%28FNH%29 Accessed March 03, 2011
    PubMedGoogle Scholar