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Int J Sports Med 2012; 33(01): 67-75
DOI: 10.1055/s-0031-1285865
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

AVPR2 Gene and Weight Changes During Triathlons

L. de Milander
1   Human Biology, University of Cape Town, South Africa
,
M. A. Kun
1   Human Biology, University of Cape Town, South Africa
,
A. V. September
1   Human Biology, University of Cape Town, South Africa
,
M. P. Schwellnus
1   Human Biology, University of Cape Town, South Africa
,
T. D. Noakes
1   Human Biology, University of Cape Town, South Africa
,
M. Collins
2   Research Unit for Exercise Science and Sports Medicine, South African Medical Research Council, Cape Town, South Africa
1   Human Biology, University of Cape Town, South Africa
› Author Affiliations
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Publication History



accepted after revision 11 July 2011

Publication Date:
03 November 2011 (online)

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Abstract

The arginine vasopressin receptor 2 (AVPR2) plays an important antidiuretic role in regulating water balance to maintain osmotic equilibrium. The aim of this study was to determine if there were any associations between single nucleotide polymorphisms (SNPs), within the AVPR2 gene, and changes in serum sodium concentrations and/or body weight (BW) in Ironman triathletes. Caucasian male triathletes who completed either the 2000, 2001 or 2006 South African Ironman Triathlons were genotyped (n=570) for at least one SNP. Pre- and post-race serum [Na+] (pre n=514; post n=423) and BWs (pre n=556; post n=552) were measured. Triathletes were divided into 3 groups according to their relative BW loss during the triathlon (BW loss of 0–3, 3–5 and >5%). There was a significant linear trend (p=0.010, x2=6.7) for the distribution of minor haplotypes GCT, GTC and GCC across the 3 BW loss groups. The >5% group had the highest percentage (4.7%) of triathletes with minor haplotypes followed by the 3–5% (3.6%) and 3–0% (0%) groups. In conclusion, the minor haplotype constructs of AVPR2 SNPs were associated with larger BW losses during the Ironman Triathlons. This finding supports a possible genetic contribution to BW loss during endurance exercise events acting through the argine vasopression system.

Key words

fluid balance - water homeostasis - electrolyte
 

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