Abstract
During research planning and the development of ideas, organic
chemists intuitively work on the chemical space, even if they are
often unaware of the nature and the extent of chemical space of
organic reactions, in which they are moving. The exploration and
the rational analysis of new chemical spaces originating from new
tandem and multicomponent aldol additions of active methylene compounds
can lead to the development of new efficient and environmentally
friendly methodologies and to the synthesis of new libraries of
highly functionalised compounds.
1 Introduction
2 Chemical Space of the Aldol Addition of Active Methylene Compounds
3 One-Pot Tandem Aldol Addition-Cyclization Reactions
4 Analysis of Chemical Spaces
Key words
aldol addition - active methylene compounds - tandem aldol
addition-cyclization - multicomponent reactions
References and Notes
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