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Semin Thromb Hemost 2011; 37(7): 756-762
DOI: 10.1055/s-0031-1297166
© Thieme Medical Publishers

Clinical and Laboratory Assessment of the Bleeding Pediatric Patient

Shoshana Revel-Vilk1
  • 1Department of Pediatric Hematology/Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
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Publication History

Publication Date:
20 December 2011 (online)

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ABSTRACT

Children presenting with bleeding symptoms pose a diagnostic challenge. The evaluation should include a comprehensive medical and bleeding history, detailed family history, a physical examination, and selected laboratory tests. Evaluation of the bleeding history should include an objective quantitation of the bleeding symptoms, followed by objective quantitation of the family members' bleeding symptoms. If a bleeding disorder is suspected, based on personal and/or family bleeding history, specific laboratory testing is needed for attaining a diagnosis. The screening tests for coagulation factor deficiencies are considered reliable, routinely available, and easy to perform. However, for primary hemostatic defects, the various screening tests have not yet proven to be reliable and thus referral for a specialized hematology consultation and specific laboratory testing are needed. Perhaps a Bayes theorem approach, combining the personal and family bleeding history with the results of a screening test for a primary hemostatic defect would prove to be useful in the identification of those children who will most benefit from specific laboratory testing.

KEYWORDS

Bleeding disorder - assessment - children - bleeding questionnaires - laboratory screening

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Shoshana Revel-VilkM.D. M.Sc. 

Department of Pediatric Hematology/Oncology, Hadassah Hebrew University Hospital

POB 12000, Jerusalem 91200, Israel

Email: shoshanav@hadassah.org.il