Geburtshilfe Frauenheilkd 2012; 72(6): 527-531
DOI: 10.1055/s-0031-1298624
Original Article
GebFra Science
Georg Thieme Verlag KG Stuttgart · New York

Impact of Phytoestrogens on Serum Lipids in Postmenopausal Women

Auswirkungen von Phytoöstrogenen auf die Serumlipide bei postmenopausalen Frauen
M. Terzic
1   Obstetrics and Gynecology, School of Medicine, University of Belgrade, Belgrade, Serbia
,
J. Micic
2   Clinical Center of Serbia, Institute of Obstetrics and Gynecology, School of Medicine, University of Belgrade, Belgrade, Serbia
,
J. Dotlic
3   Clinical Center of Serbia, Institute of Obstetrics and Gynecology, Belgrade, Serbia
,
S. Maricic
4   General Health Center “Savski Venac”, Belgrade, Serbia
,
T. Mihailovic
5   Ultramedica Clinic, American Medical Academy, Belgrade, Serbia
,
N. Knezevic
6   Department of Anesthesiology, University of Illinois; Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, United States
› Author Affiliations
Further Information

Publication History

received 25 March 2012
revised 23 April 2012

accepted 23 April 2012

Publication Date:
02 July 2012 (online)

Abstract

Objectives: The aim of the study was to assess the impact of soy- and red clover-derived isoflavones on serum lipid levels in postmenopausal women and to compare the effects to the lipid levels of healthy postmenopausal women without phytoestrogen supplementation. Materials and Methods: Blood levels of triglycerides, total cholesterol and cholesterol fractions were assessed. Measurements were performed before treatment and at 6-month intervals over a period of 18 months. The investigation included 74 healthy postmenopausal women randomized into three groups according to treatment. The first group of 23 patients received soy-derived isoflavones, the second group (26 patients) was given red clover-derived phytoestrogens, while the third control group (25 patients) received no supplements. Results: Mean triglyceride, cholesterol and LDL levels of patients in the control group were significantly higher than in both the soy and the red clover groups (p < 0.001) at all three time points, while mean values did not differ significantly between the soy and the red clover groups. The mean HDL levels of patients in the control group was significantly lower than in both the soy and the red clover groups (p < 0.001). Conclusions: Phytoestrogen supplementation had a positive metabolic effect on serum lipid levels in postmenopausal women. The impact on serum lipids levels was similar for soy and red clover.

Zusammenfassung

Ziele: Ziel der Studie war es, den Einfluss von Soja und Rotklee-Isoflavonen auf den Serumlipidspiegel von Frauen nach den Wechseljahren zu beurteilen und die Auswirkungen dieser Isoflavone mit den Blutfettwerten von gesunden postmenopausalen Frauen ohne Phytoöstrogen-Zugabe zu vergleichen. Materialien und Methoden: Die Blutwerte für Triglyzeride, Gesamtcholesterin und Cholesterinfraktionen wurden gemessen. Blutfettwertmessungen wurden vor der Behandlung und in Abständen von 6 Monaten über einen Zeitraum von 18 Monaten durchgeführt. Es wurden 74 gesunde Frauen nach den Wechseljahren untersucht, die nach dem Zufallsprinzip in 3 Gruppen unterteilt wurden. Die 1. Gruppe von 23 Patientinnen erhielt ein Präparat mit Soja-Isoflavonen, die 2. Gruppe bestand aus 26 Patientinnen, welche Rotklee-Phytoöstrogene erhielten, während die 3. aus 25 Patientinnen bestehende Gruppe als Kontrollgruppe fungierte und keine Isoflavone erhielt. Ergebnisse: Untersuchungen der Blutwerte aller Behandlungsgruppen zeigten, dass Triglyzeride, Cholesterin und LDL-Werte von Patientinnen der Kontrollgruppe signifikant höher waren als in den Soja- und Rotklee-Gruppen (p < 0,001), während die Mittelwerte zwischen der Soja- und der Rotklee-Gruppe sich nicht signifikant unterschieden. Der HDL-Spiegel von Patientinnen der Kontrollgruppe war signifikant niedriger als der in den Soja- und Rotklee-Gruppen gemessene Wert (p < 0,001). Schlussfolgerung: Die Zugabe von Phytoöstrogen hat eine positive Auswirkung auf den Serumlipidspiegel von Frauen nach den Wechseljahren. Der Einfluss von Soja und Rotklee auf den Serumlipidspiegel unterscheidet sich nicht wesentlich.

 
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