Nitro-Oxidative Stress Biomarkers in Active and Inactive Men

L. Bjork; N. T. Jenkins; S. Witkowski; J. M. Hagberg

doi:10.1055/s-0032-1301891

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2012; 33(04): 279-284
DOI: 10.1055/s-0032-1301891

Physiology & Biochemistry

Nitro-Oxidative Stress Biomarkers in Active and Inactive Men

Authors

L. Bjork

²University of Maryland, Department of Kinesiology, College Park, United States
N. T. Jenkins

²University of Maryland, Department of Kinesiology, College Park, United States
S. Witkowski

²University of Maryland, Department of Kinesiology, College Park, United States
J. M. Hagberg

²University of Maryland, Department of Kinesiology, College Park, United States

Abstract

Oxidative stress markers are novel factors shown to be related to cardiovascular (CVD) risk. We examined the effects of long-term exercise, age, and their interaction on plasma oxidized LDL (ox-LDL), nitrotyrosine, and myeloperoxidase (MPO) levels, all biomarkers of oxidative stress, and determined their association with plasma nitric oxide (NOx) levels as an index of NO bioavailability. Older (62±2 yr) active men (n=12) who had exercised for >30 years and young (25±4 yr) active men (n=7) who had exercised for >3 years were age- and BMI-matched to older (n=11) and young (n=8) inactive men. Young subjects had lower plasma nitrotyrosine levels than older subjects (P=0.047). Young inactive subjects had higher ox-LDL levels than either the young active (P=0.042) or the older active (P=0.041) subjects. In addition, plasma oxidative stress levels, particularly ox-LDL, were correlated with various conventional plasma lipoprotein-lipid levels, and in older subjects were associated with Framingham risk score (r=0.49, P=0.015). We found no relationships between plasma oxidative stress markers and NOx levels. The findings suggest that a sedentary lifestyle may be associated with higher ox-LDL levels and that the levels of oxidative stress markers are related to levels of other conventional CVD risk factors and overall CVD risk.

Key words

exercise training - nitric oxide - reactive oxygen species - aging

Full Text

References

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