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Int J Sports Med 2012; 33(04): 279-284
DOI: 10.1055/s-0032-1301891
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Nitro-Oxidative Stress Biomarkers in Active and Inactive Men

L. Bjork
2   University of Maryland, Department of Kinesiology, College Park, United States
,
N. T. Jenkins
2   University of Maryland, Department of Kinesiology, College Park, United States
,
S. Witkowski
2   University of Maryland, Department of Kinesiology, College Park, United States
,
J. M. Hagberg
2   University of Maryland, Department of Kinesiology, College Park, United States
› Author Affiliations
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Publication History



accepted after revision 05 January 2012

Publication Date:
29 February 2012 (online)

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Abstract

Oxidative stress markers are novel factors shown to be related to cardiovascular (CVD) risk. We examined the effects of long-term exercise, age, and their interaction on plasma oxidized LDL (ox-LDL), nitrotyrosine, and myeloperoxidase (MPO) levels, all biomarkers of oxidative stress, and determined their association with plasma nitric oxide (NOx) levels as an index of NO bioavailability. Older (62±2 yr) active men (n=12) who had exercised for >30 years and young (25±4 yr) active men (n=7) who had exercised for >3 years were age- and BMI-matched to older (n=11) and young (n=8) inactive men. Young subjects had lower plasma nitrotyrosine levels than older subjects (P=0.047). Young inactive subjects had higher ox-LDL levels than either the young active (P=0.042) or the older active (P=0.041) subjects. In addition, plasma oxidative stress levels, particularly ox-LDL, were correlated with various conventional plasma lipoprotein-lipid levels, and in older subjects were associated with Framingham risk score (r=0.49, P=0.015). We found no relationships between plasma oxidative stress markers and NOx levels. The findings suggest that a sedentary lifestyle may be associated with higher ox-LDL levels and that the levels of oxidative stress markers are related to levels of other conventional CVD risk factors and overall CVD risk.

Key words

exercise training - nitric oxide - reactive oxygen species - aging
 

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