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J Neurol Surg A Cent Eur Neurosurg 2013; 74(04): 262-264
DOI: 10.1055/s-0032-1304218
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Exophytic Glioblastoma Arising from the Cerebellum: Case Report and Critical Review of the Literature

Thomas Linsenmann
1   Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Bavaria, Germany
,
Camelia Maria Monoranu
2   Department of Neuropathology, University of Wuerzburg, Wuerzburg, Bavaria, Germany
,
Thomas Westermaier
1   Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Bavaria, Germany
,
Csanad Varallyay
3   Department of Neuroradiology, University of Wuerzburg, Wuerzburg, Bavaria, Germany
,
Ralf-Ingo Ernestus
1   Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Bavaria, Germany
,
Giles Hamilton Vince
1   Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Bavaria, Germany
› Author Affiliations
Further Information

Publication History

14 April 2011

07 October 2011

Publication Date:
09 July 2012 (online)

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Abstract

Exophytic glioblastoma arising from the cerebellar tonsil is an extremely rare variant within the possible anatomical presentations of the glioblastoma multiforme (GBM). We report the case of a 55-year-old woman who presented with a tumor located at the cranio-cervical junction with compression of the medulla oblongata and consecutive hydrocephalus. Due to the radiological presentation, the first tentative diagnosis was a meningioma. The tumor was microsurgically removed. Histopathological examination of the tumor revealed a GBM WHO IV. The patient underwent a postoperative percutaneous radiotherapy and concomitant chemotherapy with temozolomide. GBM should be also considered in the differential diagnosis of cerebellar tumors.

Keywords

glioblastoma - cerebellar - exophytic
 

  • References

  • 1 Yamamoto M, Fukushima T, Sakamoto S , et al. Cerebellar gliomas with exophytic growth—three case reports. Neurol Med Chir (Tokyo) 1997; 37 (5) 411-415
    CrossrefPubMedGoogle Scholar
  • 2 Stupp R, Mason WP, van den Bent MJ , et al; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352 (10) 987-996
    CrossrefPubMedGoogle Scholar
  • 3 Henson JW. Treatment of glioblastoma multiforme: a new standard. Arch Neurol 2006; 63 (3) 337-341
    CrossrefPubMedGoogle Scholar
  • 4 DeAngelis LM. Brain tumors. N Engl J Med 2001; 344 (2) 114-123
    CrossrefPubMedGoogle Scholar
  • 5 Grahovac G, Tomac D, Lambasa S, Zoric A, Habek M. Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir (Wien) 2009; 151 (6) 653-657
    CrossrefPubMedGoogle Scholar
  • 6 Kuroiwa T, Numaguchi Y, Rothman MI , et al. Posterior fossa glioblastoma multiforme: MR findings. AJNR Am J Neuroradiol 1995; 16 (3) 583-589
    PubMedGoogle Scholar
  • 7 Stark AM, Nabavi A, Mehdorn HM, Blömer U. Glioblastoma multiforme-report of 267 cases treated at a single institution. Surg Neurol 2005; 63 (2) 162-169 , discussion 169
    CrossrefPubMedGoogle Scholar
  • 8 Weber DC, Miller RC, Villà S , et al. Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the Rare Cancer Network. Int J Radiat Oncol Biol Phys 2006; 66 (1) 179-186
    CrossrefPubMedGoogle Scholar
  • 9 de la Fuente BP, Dalmau J, Rosenfeld M. [Glioma therapy up-date]. Neurologia 2007; 22 (3) 159-169
    PubMedGoogle Scholar
  • 10 Saito T, Hama S, Kajiwara Y , et al. Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas. Anticancer Res 2006; 26 (2B) 1351-1357
    PubMedGoogle Scholar