Kardiologie up2date 2012; 8(1): 10-15
DOI: 10.1055/s-0032-1306679
Hotline ‐ Herzinsuffizienz

© Georg Thieme Verlag KG Stuttgart · New York

Therapiemonitoring bei chronischer Herzinsuffizienz mittels BNP und NT-proBNP

Markus  Haass, Stefan  Störk
Further Information

Publication History

Publication Date:
28 March 2012 (online)


Up to now, monitoring of chronic heart failure essentially is refined to serial assessment of NYHA functional class and echocardiographically measured parameters such as left ventricular ejection fraction. The B-type natriuretic peptide (BNP) and the N-terminal fragment of its prohormone (NT-proBNP) reflect myocardial wall stress and are associated with the severity and prognosis of heart failure. In recent years, several controlled trials investigated the value of these natriuretic peptides in monitoring the clinical course and optimizing the pharmacological treatment of patients with heart failure. Metaanalyses suggest that a natriuretic peptide guided strategy may decrease the mortality risk in patients below the age of 75 years. By contrast, effects on cardiovascular or heart failure related hospitalisation were inconclusive. Thus, BNP and NT-proBNP may be used to monitor the clinical course of patients with chronic heart failure. However, the utility of a natriuretic peptide guided approach to improve the individual course of disease under real-world conditions is still unclear. Larger trials with less selected patient populations and longer follow-up time are needed to pursue this topic.


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Prof. Dr. med. Markus Haass

Innere Medizin II (Kardiologie, Angiologie und Internistische Intensivmedizin)

Bassermannstr. 1
68165 Mannheim

Email: [email protected]

Prof. Dr. med. Stefan Störk

Deutsches Zentrum für Herzinsuffizienz Würzburg
Universitätsklinikum und Universität Würzburg

Straubmühlweg 2a
97078 Würzburg

Email: [email protected]