J Knee Surg 2012; 25(01): 031-036
DOI: 10.1055/s-0032-1308822
Special Focus Section
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Nontraditional Modification to Articular Cartilage

Vasili Karas
1  Division of Sports Medicine, Department of Orthopedics, Rush University Medical Center, Chicago, Illinois
,
Neil Ghodadra
2  Division of Sports Medicine, Department of Orthopedics, Southern California Orthopedic Institute, Van Nuys, California
,
Ellen Kroin
1  Division of Sports Medicine, Department of Orthopedics, Rush University Medical Center, Chicago, Illinois
,
Brian J. Cole
1  Division of Sports Medicine, Department of Orthopedics, Rush University Medical Center, Chicago, Illinois
› Author Affiliations
Further Information

Publication History

08 November 2011

28 December 2011

Publication Date:
12 April 2012 (online)

Abstract

Biomechanical imbalance, trauma, and age-related degeneration often result in chondral lesions, which may lead to overt osteoarthritis over time. Such cartilage pathology is frequently accompanied by persistent pain and loss of normal joint function. As a result, patients who suffer from biologically active articular cartilage lesions are often unable to function in both high level activities and exhibit compromised activities of daily living. The limited potential for self-regeneration of hyaline cartilage has led to the emergence of new technologies to solve this difficult clinical problem. Treatment of arthritis and chondral lesions includes alleviation of pain and return of function through pharmacologic intervention and/or attempts at cartilage reparative, restorative and reconstructive options.