Ultraschall Med 2012; 33(4): 344-351
DOI: 10.1055/s-0032-1313026
Consensus Paper
© Georg Thieme Verlag KG Stuttgart · New York

An EFSUMB Introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for Quantification of Tumour Perfusion

Einführung des „Dynamic Contrast-Enhanced Ultrasound (DCE-US)“ zur Quantifizierung der Tumorperfusion, EFSUMB-Statement
C. F. Dietrich*
1   Innere Medizin 2, Caritas-Krankenhaus, Bad Mergentheim
M. A. Averkiou*
2   Department of Mechanical and Manufacturing Engineering, University of Cyprus
J.-M. Correas
3   Service de Radiologie adultes, Hôpital Necker, 149 rue de Sèvres, Université Paris Descartes
N. Lassau
4   Imaging Department, Institut Gustave Roussy
E. Leen
5   Imaging Department, Imperial College London
F. Piscaglia
6   Dept of Internal Medicine and Gastroenterology, Div. Internal Medicine, Bologna
› Author Affiliations
Further Information

Publication History

06 June 2012

25 June 2012

Publication Date:
27 July 2012 (online)


Dynamic Contrast Enhanced Ultrasound (DCE-US) is an imaging technique that utilizes microbubble contrast agents in diagnostic ultrasound. The EFSUMB guidelines published in 2004, updated in 2008 and 2011 focused on the use of DCE-US, including essential technical requirements, training, investigational procedures and steps, guidance on image interpretation, established and recommended clinical indications and safety considerations. However the quantification of images acquired with ultrasound contrast agents (UCAs) is not discussed in the guidelines. The purpose of this EFSUMB document is to provide some recommendations and descriptions of the quantification of ultrasound images, technical requirements for analysis of time-intensity curves (TICs), methodology for data analysis, and interpretation of the results.


Dynamic Contrast Enhanced Ultrasound (DCE-US) ist eine Quantifizierungstechnik des kontrastverstärkten Ultraschalls. Die EFSUMB-Leitlinien 2004, 2008 und 2011 erläutern die Grundlagen für Ultraschallkontrastmitteltechniken, geben aber keine detaillierte Information zu den Anwendungsmöglichkeiten, Vorgehensweise und Besonderheiten von DCE-US. Ziel dieses EFSUMB-Dokuments ist es, notwendige Grundlagen, technischen Voraussetzungen für die Analyse von Zeit-Intensitäts-Kurven und den (standardisierten) Ablauf der Daten-Analyse und Empfehlung zur Interpretation zu geben.

* Both authors contributed equally to this manuscript.

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