J Neurol Surg A Cent Eur Neurosurg 2013; 74(02): 116-119
DOI: 10.1055/s-0032-1313637
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Recurrent Giant Cell Glioblastoma with the Neuroradiologic Picture of Multiple Meningiomas[*]

U. Nestler
1   Justus Liebig University, Neurosurgery, Giessen, Germany
D. Schulz
1   Justus Liebig University, Neurosurgery, Giessen, Germany
F. A. Wanis
1   Justus Liebig University, Neurosurgery, Giessen, Germany
C. Zuehlke
2   Justus Liebig University, Neuroradiology, Giessen, Germany
A. Schaenzer
3   Justus Liebig University, Neuropathology, Giessen, Germany
P. Christophis
1   Justus Liebig University, Neurosurgery, Giessen, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
01 August 2012 (online)


We present here the case of a recurrent giant cell glioblastoma with the neuroradiological and surgical aspects of multiple meningiomas. Evidence exists indicating that gliosarcomas resembling meningiomas can be removed more completely and possess a better prognosis for survival. In contrast, this case of giant cell glioblastoma with its rare type of multifocal recurrence showed rapid growth and a very grim prognosis for the patient.

* This article was originally published online in Central European Neurosurgery on January 12, 2012 (DOI:10.1055/s-0031-1279749)

  • References

  • 1 Davila G, Duyckaerts C, Lazareth JP , et al. Diffuse primary leptomeningeal gliomatosis. J Neurooncol 1993; 15: 45-49
  • 2 Deb P, Sharma MC, Chander B , et al. Giant cell glioblastoma multiforme: report of a case with prolonged survival and transformation to gliosarcoma. Childs Nerv Syst 2006; 22: 314-319
  • 3 Han SJ, Yang I, Ahn BJ , et al. Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients. Cancer 2010; 116: 1358-1366
  • 4 Kwak R, Shatzkes D. Transdural spread of glioblastoma through the foramen ovale with presentation as a masticator space mass. AJNR Am J Neuroradiol 2009; 30: 808-810
  • 5 Lim DA, Cha S, Mayo MC , et al. Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neuro Oncol 2007; 9: 424-429
  • 6 Liwnicz BH, Rubinstein LJ. The pathways of extraneural spread in metastasizing gliomas: a report of three cases and critical review of the literature. Human Pathol 1979; 10: 453-467
  • 7 Louis DN, Ohgaki H, Wiestler OD , et al (eds). WHO classification of tumours of the central nervous system. 4th edition. IARC: Lyon; 2007
  • 8 Maiuri F, Stella L, Benvenuti D , et al. Cerebral gliosarcomas: correlation of computed tomographic findings, surgical aspect, pathological features, and prognosis. Neurosurgery 1990; 26: 261-267
  • 9 Opeskin K, Anderson RM, Nye DH. Primary meningeal glioma. Pathology 1994; 26: 72-74
  • 10 Shuangshoti S, Kasantikul V, Suwanwela N , et al. Solitary primary intracranial extracerebral glioma. Case report. J Neurosurg 1984; 61: 777-781
  • 11 Suzuki K, Momota H, Tonooka A , et al. Glioblastoma simultaneously present with adjacent meningioma: case report and review of the literature. J Neurooncol 2010; 99: 147-153
  • 12 Wakabayashi K, Shimura T, Mizutani N , et al. Primary intracranial solitary leptomeningeal glioma: a report of 3 cases. Clin Neuropathol 2002; 21: 206-213