Synthesis, Table of Contents Synthesis 2012; 44(23): 3590-3594DOI: 10.1055/s-0032-1317161 practical synthetic procedures © Georg Thieme Verlag Stuttgart · New YorkEnantioselective Synthesis of Substituted Indoles Through Zirconium(IV)-Catalyzed Friedel–Crafts Alkylation Authors Author Affiliations Gonzalo Blay Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot (València), Spain , Fax: +34(963)544328 Email: jose.r.pedro@uv.es Isabel Fernández Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot (València), Spain , Fax: +34(963)544328 Email: jose.r.pedro@uv.es José R. Pedro* Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot (València), Spain , Fax: +34(963)544328 Email: jose.r.pedro@uv.es Carlos Vila Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot (València), Spain , Fax: +34(963)544328 Email: jose.r.pedro@uv.es Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Abstract The chiral complex of (R)-3,3′-Br2-BINOL and zirconium tert-butoxide catalyzes the Friedel–Crafts alkylation of indoles with enones bearing an alkyl or fluorinated group at the β-position to give indoles having a side chain at the C3 position with a tertiary stereogenic center in good yields and with excellent enantioselectivities. Key words Key wordsasymmetric catalysis - fluorine - enones - heterocycles - indoles - Michael addition - zirconium Full Text References References 1a Wu Y.-J. 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