J Neurol Surg A Cent Eur Neurosurg 2013; 74(S 01): e13-e17
DOI: 10.1055/s-0032-1320024
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Solitary Plasmacytoma Presenting as an Intramedullary Mass of the Cervical Cord

Franz Josef Hans
1   Department of Neurosurgery, University Hospital (RWTH), Aachen, Germany
,
Sasikhan Geibprassert
2   Department of Neuroradiology, University of Toronto, Toronto, Ontario, Canada
,
Timo Krings
2   Department of Neuroradiology, University of Toronto, Toronto, Ontario, Canada
,
Joachim Weis
3   Institute of Neuropathology, RWTH Aachen University, Aachen, Germany
,
Martina Deckert
4   Department of Neuropathology, University Hospital Cologne, Cologne, Germany
,
Alexander Ludolph
5   Department of Neuroradiology, University Hospital (RWTH), Aachen, Germany
,
Rainhardt Osieka
6   Department of Internal Medicine IV, University Hospital (RWTH), Aachen, Germany
,
Edgar Jost
6   Department of Internal Medicine IV, University Hospital (RWTH), Aachen, Germany
› Institutsangaben
Weitere Informationen

Publikationsverlauf

15. September 2011

26. Januar 2012

Publikationsdatum:
11. Dezember 2012 (online)

Abstract

Extramedullary plasmacytomas originating in the spinal cord are extremely rare lesions. We report a 52-year-old man presenting with progressive tetraparesis. Spinal magnetic resonance imaging (MRI) showed an ill-defined contrast-enhancing intramedullary mass at the C5-6 level. After a biopsy was taken, pathology including immunohistochemistry revealed plasmacytoma. Complete workup for multiple myeloma was negative. The patient was treated with intravenous chemotherapy followed by radiotherapy and corticosteroids without any improvement of the clinical symptoms or decreased tumor size on the follow-up MRIs. The most common spinal manifestation of plasmocytoma is involvement of the vertebral bodies leading to extradural compression of the cord. Only rarely plasmocytoma manifests itself as a primarily dural lesion leading to an intradural cord compression. This report describes the extremely rare manifestation of plasmocytoma of the spinal cord itself that therefore should be considered in the differential diagnosis of spinal cord mass lesions.

 
  • References

  • 1 Galieni P, Cavo M, Pulsoni A , et al. Clinical outcome of extramedullary plasmacytoma. Haematologica 2000; 85 (1) 47-51
  • 2 Alexiou C, Kau RJ, Dietzfelbinger H , et al. Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer 1999; 85 (11) 2305-2314
  • 3 Dimopoulos MA, Hamilos G. Solitary bone plasmacytoma and extramedullary plasmacytoma. Curr Treat Options Oncol 2002; 3 (3) 255-259
  • 4 Provenzale JM, Schaefer P, Traweek ST , et al. Craniocerebral plasmacytoma: MR features. AJNR Am J Neuroradiol 1997; 18 (2) 389-392
  • 5 Hayes-Lattin B, Blanke CD, Deloughery TG. Pulmonary and intracerebral plasmacytomas in a patient without multiple myeloma: a case report. Am J Hematol 2003; 73 (2) 131-134
  • 6 Gao B, Wang X. An extramedullary plasmacytoma originating from the thoracic spinal cord: magnetic resonance imaging findings. Case report. J Neurosurg Spine 2007; 6 (1) 57-59
  • 7 Zazpe I, Caballero C, Cabada T, Guerrero D, Gallo-Ruiz A, Portillo E. Solitary thoracic intradural extramedullary plasmacytoma. Acta Neurochir (Wien) 2007; 149 (5) 529-532 , discussion 532
  • 8 Sod LM, Wiener LM. Intradural extramedullary plasmacytoma; case report. J Neurosurg 1959; 16 (1) 107-109
  • 9 Fonti R, Salvatore B, Quarantelli M , et al. 18F-FDG PET/CT, 99mTc-MIBI, and MRI in evaluation of patients with multiple myeloma. J Nucl Med 2008; 49 (2) 195-200
  • 10 Hur J, Yoon CS, Ryu YH, Yun MJ, Suh JS. Comparative study of fluorodeoxyglucose positron emission tomography and magnetic resonance imaging for the detection of spinal bone marrow infiltration in untreated patients with multiple myeloma. Acta Radiol 2008; 49 (4) 427-435
  • 11 Lin P, Owens R, Tricot G, Wilson CS. Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma. Am J Clin Pathol 2004; 121 (4) 482-488
  • 12 Bachar G, Goldstein D, Brown D , et al. Solitary extramedullary plasmacytoma of the head and neck—long-term outcome analysis of 68 cases. Head Neck 2008; 30 (8) 1012-1019
  • 13 Liebross RH, Ha CS, Cox JD, Weber D, Delasalle K, Alexanian R. Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol 1999; 52 (3) 245-249
  • 14 Patriarca F, Zaja F, Silvestri F , et al. Meningeal and cerebral involvement in multiple myeloma patients. Ann Hematol 2001; 80 (12) 758-762