Dtsch Med Wochenschr 2013; 138(05): 172-175
DOI: 10.1055/s-0032-1327412
Endokrinologie und Diabetologie | Commentary
Endokrinologie
© Georg Thieme Verlag KG Stuttgart · New York

Adipositas und Inflammation

Obesity and inflammation
J. Gräßler
1   Medizinische Klinik und Poli- klinik III, Universitätsklinikum Carl-Gustav Carus, TU Dresden
,
M. Blüher
2   Klinik und Poliklinik für Endo- krinologie und Nephrologie, Universitätsklinikum Leipzig , *gleichwertiger Autorenbeitrag
,
T. Chavakis
1   Medizinische Klinik und Poli- klinik III, Universitätsklinikum Carl-Gustav Carus, TU Dresden
› Author Affiliations
Further Information

Publication History

Publication Date:
22 January 2013 (online)

 
  • Literatur

  • 1 Arumugam M, Raes J, Pelletier E et al. Enterotypes of the human gut microbiome. Nature 2011; 473: 174-180
  • 2 Backhed F, Ding H, Wang T et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004; 101: 15718-15723
  • 3 Blüher M. Are there still healthy obese patients?. Curr Opin Endocrinol Diabetes Obes 2012; 19: 341-346
  • 4 Cani PD, Delzenne NM, Amar J et al. Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding. Pathol Biol (Paris) 2008; 56: 305-309
  • 5 Chatzigeorgiou A, Karalis KP, Bornstein SR et al. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia 2012; 55: 2583-2592
  • 6 Divoux A, Moutel S, Poitou C et al. Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes. J Clin Endocrinol Metab 2012; 97: E1677-85
  • 7 Graessler J, Qin Y, Zhong H et al. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters. Pharmacogenomics J 2012;
  • 8 Halberg N, Khan T, Trujillo ME et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009; 29: 4467-4483
  • 9 Klöting N, Fasshauer M, Dietrich A et al. Insulin-sensitive obesity. Am J Physiol Endocrinol Metab 2010; 299: E506-15
  • 10 Larsen N, Vogensen FK, van den Berg FW et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 2010; 5: e9085
  • 11 Ley RE, Backhed F, Turnbaugh P et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 2005; 102: 11070-11075
  • 12 Maixner N, Kovsan J, Harman-Boehm I et al. Autophagy in adipose tissue. Obes Facts 2012; 5: 710-721
  • 13 Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012; 18: 363-374
  • 14 Pal D, Dasgupta S, Kundu R et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 2012; Jul 29. doi: DOI: 10.1038/nm.2851.
  • 15 Qin J, Li R, Raes J et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59-65
  • 16 Saberi M, Woods NB, de Luca C et al. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab 2009; 10: 419-429
  • 17 Schwiertz A, Taras D, Schafer K et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010; 18: 190-195
  • 18 Talukdar S, Oh DY, Bandyopadhyay G et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med 2012; Aug [Epub ahead of print]
  • 19 Thum C, Cookson AL, Otter DE et al. Can nutritional modulation of maternal intestinal microbiota influence the development of the infant gastrointestinal tract?. J Nutr 2012; 142: 1921-1922
  • 20 Turnbaugh PJ, Hamady M, Yatsunenko T et al. A core gut microbiome in obese and lean twins. Nature 2009; 457: 480-484
  • 21 Wang J, Shi GP. Mast cell stabilization: novel medication for obesity and diabetes. Diabetes Metab Res Rev 2011; 27: 919-924
  • 22 Weisberg SP, McCann D, Desai M et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-1808
  • 23 Winer DA, Winer S, Shen L et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 2011; 17: 610-617
  • 24 Wu D, Molofsky AB, Liang HE et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011; 332: 243-247