Aktuelle Kardiologie 2013; 2(1): 43-46
DOI: 10.1055/s-0032-1328149
Kasuistik
Georg Thieme Verlag KG Stuttgart · New York

Nierenarterienembolie als klinische Erstmanifestation von paroxysmalem Vorhofflimmern

Renal Artery Embolism as a First Clinical Manifestation of Paroxysmal Atrial Fibrillation
F. Kasch
1   Medizinische Abteilung, Kardiologie, Asklepios Klinik Harburg, Hamburg
,
B. Leithäuser
2   Neuro-Kardiologie im Zentrum, Hamburg
,
J.-W. Park
1   Medizinische Abteilung, Kardiologie, Asklepios Klinik Harburg, Hamburg
› Author Affiliations
Further Information

Publication History

Publication Date:
20 February 2013 (online)

Zusammenfassung

Der Bericht beschreibt den Fall einer spät erkannten kardiogenen Nierenarterienembolie bei Erstdiagnose von paroxysmalem Vorhofflimmern. Die Therapie erfolgte in Form einer kathetergestützten lokoregionalen Thrombolyse unter Verwendung von Gewebsplasminogenaktivator (rt-PA) und Bivalirudin zur prozeduralen Antikoagulation mit erfolgreicher Rekanalisation. Im Bereich der peripher-arteriellen Interventionen findet sich für diese Kombination bisher keine Erwähnung in der Literatur. Aufgrund der langen zeitlichen Überschreitung der Ischämietoleranz resultierte ein Funktionsausfall der betroffenen Niere trotz erfolgreicher Rekanalisation.

Abstract

A case of delayed diagnosis of cardiogenic renal embolism as a first clinical manifestation of paroxysmal atrial fibrillation is reported. Successful recanalization was achieved with catheter-directed local thrombolysis with tissue plasminogen activator (rt-PA) together with procedural anticoagulation with bivalirudin. Up to now, no publication describes the therapeutic use of this combination in the field of peripheral aterial interventions. Despite arterial recanalization the affected kidney lost its function because the ischemia tolerance period was exeeded.

 
  • Literatur

  • 1 Menke J, Luthje L, Kastrup A et al. Thromboembolism in atrial fibrillation. Am J Cardiol 2010; 105: 502-510
  • 2 Korzets Z, Plotkin E, Bernheim J et al. The clinical spectrum of acute renal infarction. IMAJ 2002; 4: 781-784
  • 3 Hazanov N, Somin M, Attali M et al. Acute renal embolism. Forty-four cases of renal infarction in patients with atrial fibrillation. Medicine (Baltimore) 2004; 83: 292-299
  • 4 Huang CC, Lo HC, Huang HH et al. ED presentations of acute renal infarction. Am J Emerg Med 2007; 25: 164-169
  • 5 Glockner JF, Vrtiska TJ. Renal MR and CT angiography: current concepts. Abdom Imaging 2007; 32: 407-420
  • 6 Chehval MJ, Mehan DJ. Nonoperative management of renal artery embolus. Urology 1979; 14: 569-572
  • 7 Camm AJ, Lip GY, De Caterina R et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012; 33: 2719-2747
  • 8 Fischer CP, Konnak JW, Cho KJ et al. Renal artery embolism: therapy with intra-arterial streptokinase infusion. J Urol 1981; 125: 402-404
  • 9 Rudy DC, Parker TW, Seigel RS et al. Segmental renal artery emboli treated with low-dose intra-arterial streptokinase. Urology 1982; 19: 410-413
  • 10 Cronan jr. JJ, Dorfman GS. Low dose thrombolysis: a nonoperative approach to renal artery occlusion. J Urol 1983; 130: 757-759
  • 11 Salam TA, Lumsden AB, Martin LG. Local infusion of fibrinolytic agents for acute renal artery thromboembolism: report of ten cases. Ann Vasc Surg 1993; 7: 21-26
  • 12 Blum U, Billmann P, Krause T et al. Effect of local low-dose thrombolysis on clinical outcome in acute embolic renal artery occlusion. Radiology 1993; 189: 549-554
  • 13 Piffaretti G, Riva F, Tozzi M et al. Catheter-directed thrombolysis for acute renal artery thrombosis: report of 4 cases. Vasc Endovasc Surg 2008; 42: 375-379
  • 14 Inoue T, Iwamura H, Kanematsu A et al. [Renal artery embolism treated by selective intra-arterial infusion of tissue plasminogen activator: report of 2 cases]. Hinyokika Kiyo 1997; 43: 655-659
  • 15 Tan TW, Bohannon WT, Mattos MA et al. Percutaneous mechanical thrombectomy and pharmacologic thrombolysis for renal artery embolism: case report and review of endovascular treatment. Int J Angiol 2011; 20: 111-116
  • 16 Greenberg JM, Steiner MA, Marshall JJ. Acute renal artery thrombosis treated by percutaneous rheolytic thrombectomy. Catheter Cardiovasc Interv 2002; 56: 66-68
  • 17 Siablis D, Liatsikos EN, Goumenos D et al. Percutaneous rheolytic thrombectomy for treatment of acute renal-artery thrombosis. J Endourol 2005; 19: 68-71
  • 18 Syed MI, Shaikh A, Ullah A et al. Acute renal artery thrombosis treated with t-PA power-pulse spray rheolytic thrombectomy. Cardiovascv Revasc Med 2010; 11: 264.e1-264.e7
  • 19 Ouriel K, Andrus CH, Ricotta JJ et al. Acute renal artery occlusion: when is revascularization justified?. J Vasc Surg 1987; 5: 348-355
  • 20 Bouttier S, Valverde JP, Lacombe M et al. Renal artery emboli: the role of surgical treatment. Ann Vasc Surg 1988; 2: 161-168
  • 21 Davutoglu V, Yildirim C, Gunay N et al. Renal infarction mimicking renal colic in patient with a prosthetic aortic valve. Emerg Med J 2005; 22: 595-596
  • 22 Majumdar A, Chowdhary S, Ferreira MA et al. Renal pathological findings in infective endocarditis. Nephrol Dial Transplant 2000; 15: 1782-1787
  • 23 Fujisaki K, Shohno Y, Yoshida T et al. Acute renal infarction in a patient with left atrial myxoma. Clin Nephrol 2007; 67: 53-57
  • 24 Tanaka M, Matsuo K, Shoda H et al. Severe hyperreninemic hypertension associated with spontaneous renal cholesterol crystal embolization. Clin Exp Nephrol 2004; 8: 150-154
  • 25 Kirchhoff PG, Henning HV, Baumgarten C et al. [Ischemia tolerance of the kidney following renal artery embolism]. Med Klin 1970; 65: 1667-1671
  • 26 Weaver FA, Comerota AJ, Youngblood M et al. Surgical revascularization versus thrombolysis for nonembolic lower extremity native artery occlusions: results of a prospective randomized trial. The STILE Investigators. Surgery versus Thrombolysis for Ischemia of the Lower Extremity. J Vasc Surg 1996; 24: 513-521
  • 27 Metz BK, White HD, Granger CB et al. Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-II b Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-II b) Investigators. J Am Coll Cardiol 1998; 31: 1493-1498
  • 28 Katzen BT, Ardid MI, MacLean AA et al. Bivalirudin as an anticoagulation agent: safety and efficacy in peripheral interventions. J Vasc Interv Radiol 2005; 16: 1183-1187
  • 29 Ndrepepa G, Schulz S, Keta D et al. Bleeding after percutaneous coronary intervention with Bivalirudin or unfractionated Heparin and one-year mortality. Am J Cardiol 2010; 105: 163-167
  • 30 White H. Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet 2001; 358: 1855-1863
  • 31 Hohnloser SH, Pajitnev D, Pogue J et al. Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy. J Am Coll Cardiol 2007; 50: 2156-2161
  • 32 Nieuwlaat R, Dinh T, Olsson SB et al. Should we abandon the common practice of withholding oral anticoagulation in paroxysmal atrial fibrillation?. Eur Heart J 2008; 29: 915-922