Leberzelltransplantationsmodelle für die experimentelle klinische Forschung – Prometheus in neuem Licht?

Schlüsselwörter

Leberzelltransplantation - Hepatozyten - translationale Forschung

Keywords

liver cell transplantation - hepatocytes - translational research

• Literatur

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• 7 Petersen J, Dandri M, Gupta S et al. Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma. Proc Natl Acad Sci U S A 1998; 95: 310-315
• 8 Tateno C, Yoshizane Y, Saito N et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol 2004; 165: 901-912
• 9 Tschaharganeh DF, Kaldenbach M, Erschfeld S et al. Glycoprotein 130-dependent pathways in host hepatocytes are important for liver repopulation in mice. Liver Transpl 2010; 16: 23-32
• 10 Uygun BE, Soto-Gutierrez A, Yagi H et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med 2010; 16: 814-820
• 11 Yagi H, Fukumitsu K, Fukuda K et al. Human-scale whole-organ bioengineering for liver transplantation: a regenerative medicine approach. Cell Transplant 2013; 22: 231-242