Laryngorhinootologie 2013; 92(S 01): S239-S257
DOI: 10.1055/s-0032-1333304
Referat
© Georg Thieme Verlag KG Stuttgart · New York

Fehler und Gefahren: Behandlung gutartiger Kehlkopferkrankungen

Diagnostic and Therapeutic Pitfalls in Benign Vocal Fold Diseases
J. Bohlender
1   Abteilung Phoniatrie und Klinische Logopädie, Klinik für Ohren-, Nasen-, Hals- und Gesichtschirurgie, UniversitätsSpital Zürich
› Author Affiliations
Further Information

Publication History

Publication Date:
26 April 2013 (online)

Zusammenfassung

Mehr als die Hälfte der Patienten, die sich bei einem HNO-Arzt mit dem Symptom einer Heiserkeit präsentieren, weisen gutartige Stimmlippenveränderungen auf. Um eine optimale, differenzierte und individuelle Betreuung des Stimmpatienten zu gewährleisten, sollte der behandelnde Arzt mit den modernen diagnostischen und therapeutischen Möglichkeiten bei gutartigen Stimmlippenerkrankungen vertraut sein. Grundlegende Kenntnisse der Ätiologie bilden die Voraussetzung für eine zielgerichtete konservative wie phonochirurgische Therapie.

Im Mittelpunkt der vorliegenden Übersichtsarbeit stehen die diagnostischen und therapeutischen Grenzen sowie die Schwierigkeiten bei der Behandlung von gutartigen Stimmlippentumoren. Darüberhinaus werden das Management und die Prophylaxe von narbigen Stimmlippenveränderungen und abschließend das Thema der einseitigen Stimmlippenlähmung diskutiert.

Abstract

Diagnostic and Therapeutic Pitfalls in Benign Vocal Fold Diseases

More than half of patients who present with the symptom of hoarseness show benign vocal fold changes. The clinician should be familiar with modern diagnostic and therapeutic possibilities of benign vocal fold changes in order to ensure an optimal and individualized attention to voice patients. Basic knowledge of the etiology are provided for targeted phonosurgical or conservative therapy. This review article focuses on the diagnostic and therapeutic limitations and difficulties of treatment of benign vocal fold tumors, the management and prophylaxis of scarred vocal fold changes and the issue of unilateral vocal fold paralysis.

 
  • Literatur

  • 1 Zeitels SM, Healy GB. Laryngology and phonosurgery. N Engl J Med 2003; 349: 882-892
  • 2 Cohen SM, Kim J, Roy N, Asche C, Courey M. The impact of laryngeal disorders on work-related dysfunction. Laryngoscope 2012; 122: 1589-1594
  • 3 Altman KW. Vocal fold masses. Otolaryngol Clin North Am 2007; 40: 1091-1108, viii
  • 4 Sataloff RTG. Paul Moore Lecture. Rational thought: the impact of voice science upon voice care. J Voice 1995; 9: 215-234
  • 5 Johns MM. Update on the etiology, diagnosis, and treatment of vocal fold nodules, polyps, and cysts. Curr Opin Otolaryngol Head Neck Surg 2003; 11: 456-461
  • 6 Roy N, Merrill RM, Gray SD, Smith EM. Voice disorders in the general population: prevalence, risk factors, and occupational impact. Laryngoscope 2005; 115: 1988-1995
  • 7 Hantzakos A, Remacle M, Dikkers FG, Degols JC, Delos M, Friedrich G, Giovanni A, Rasmussen N. Exudative lesions of Reinke’s space: a terminology proposal. Eur Arch Otorhinolaryngol 2009; 266: 869-878
  • 8 Oates J, Winkworth A. Current knowledge, controversies and future directions in hyperfunctional voice disorders. Int J Speech Lang Pathol 2008; 10: 267-277
  • 9 Sulica L. Hoarseness. Arch Otolaryngol Head Neck Surg 2011; 137: 616-619
  • 10 Gray SD, Hammond E, Hanson DF. Benign pathologic responses of the larynx. Ann Otol Rhinol Laryngol 1995; 104: 13-18
  • 11 Schneider B, Bigenzahn W. Stimmdiagnostik: Ein Leitfaden Für Die Praxis. Springer; Vienna: 2007
  • 12 Dejonckere PH, Bradley P, Clemente P, Cornut G, Crevier-Buchman L, Friedrich G, Van De Heyning P, Remacle M, Woisard V. A basic protocol for functional assessment of voice pathology, especially for investigating the efficacy of (phonosurgical) treatments and evaluating new assessment techniques. Guideline elaborated by the Committee on Phoniatrics of the European Laryngological Society (ELS). Eur Arch Otorhinolaryngol 2001; 258: 77-82
  • 13 Nawka T, Wiesmann U, Gonnermann U. Validierung des Voice Handicap Index (VHI) in der deutschen Fassung. HNO 2003; 51: 921-930
  • 14 Nawka T, Verdonck-de Leeuw IM, De Bodt M, Guimaraes I, Holmberg EB, Rosen CA, Schindler A, Woisard V, Whurr R, Konerding U. Item reduction of the voice handicap index based on the original version and on European translations. Folia Phoniatr Logop 2009; 61: 37-48
  • 15 Carding PN, Steen IN, Webb A, MacKenzie K, Deary IJ, Wilson JA. The reliability and sensitivity to change of acoustic measures of voice quality. Clin Otolaryngol Allied Sci 2004; 29: 538-544
  • 16 Carding PN, Wilson JA, MacKenzie K, Deary IJ. Measuring voice outcomes: state of the science review. J Laryngol Otol 2009; 123: 823-829
  • 17 Ptok M, Schwemmle C, Iven C, Jessen M, Nawka T. Zur auditiven Bewertung der Stimmqualität. HNO 2006; 54: 793-802
  • 18 Hirano M. Clinical Examination of Voice. Wien, New York: Springer-Verlag; 1981
  • 19 Wendler J, Seidner W, Eysholdt U. Lehrbuch Der Phoniatrie Und ­Pädaudiologie. Thieme; Stuttgart: 2005
  • 20 Nawka T, Wirth G. Stimmstörungen: Für Ärzte, Logopäden, Sprachheilpädagogen Und Sprechwissenschaftler; Mit 30 Tabellen. Köln: Dt. Ärzte-Verl.; 2008
  • 21 Carding PN, Steen IN, Webb A, MacKenzie K, Deary IJ, Wilson JA. The reliability and sensitivity to change of acoustic measures of voice quality. Clin Otolaryngol Allied Sci 2004; 29: 538-544
  • 22 Friedrich G, Dejonckere PH. Das Stimmdiagnostik-Protokoll der European Laryngological Society (ELS) – erste Erfahrungen im Rahmen einer Multizenterstudie. Laryngorhinootologie 2005; 84: 744-752
  • 23 Dejonckere PH, Remacle M, Fresnel-Elbaz E, Woisard V, Crevier L, Millet B. Reliability and clinical relevance of perceptual evaluation of pathological voices. Rev Laryngol Otol Rhinol (Bord) 1998; 119: 247-248
  • 24 DeJonckere PH, van Wijck I, Speyer R. Efficacy of voice therapy assessed with the Voice Range Profile (Phonetogram). Rev Laryngol Otol Rhinol (Bord) 2003; 124: 285-289
  • 25 Schindler A, Bottero A, Capaccio P, Ginocchio D, Adorni F, Ottaviani F. Vocal improvement after voice therapy in unilateral vocal fold paralysis. J Voice 2008; 22: 113-118
  • 26 Stajner-Katusic S, Horga D, Zrinski KV. A longitudinal study of voice before and after phonosurgery for removal of a polyp. Clin Linguist Phon 2008; 22: 857-863
  • 27 Berke GS, Gerratt BR, Hanson DG. An acoustic analysis of the effects of surgical therapy on voice quality. Otolaryngol Head Neck Surg 1983; 91: 502-508
  • 28 Schutte HK, Seidner W. Recommendation by the Union of European Phoniatricians (UEP): standardizing voice area measurement/phonetography. Folia Phoniatr. Basel; 1983. 35. 286-288
  • 29 Baken RJ, Orlikoff RF.. Clinical Measurement of Speech & Voice. 2nd Edition. Singular 1999
  • 30 Siupsinskiene N, Lycke H. Effects of vocal training on singing and speaking voice characteristics in vocally healthy adults and children based on choral and nonchoral data. J Voice 2011; 25: e177-e189
  • 31 Hacki T. Tonhöhen- und Intensitätsbefunde bei Stimmgeübten Vergleichende Sprechstimmfeld-, Rufstimmfeld- und Singstimmfeldmessung. HNO 1999; 47: 809-815
  • 32 Schneider B, Zumtobel M, Prettenhofer W, Aichstill B, Jocher W. Normative voice range profiles in vocally trained and untrained children aged between 7 and 10 years. J Voice 2010; 24: 153-160
  • 33 Hakkesteegt MM, Brocaar MP, Wieringa MH. The applicability of the dysphonia severity index and the voice handicap index in evaluating effects of voice therapy and phonosurgery. J Voice 2010; 24: 199-205
  • 34 Hakkesteegt MM, Brocaar MP, Wieringa MH, Feenstra L. The relationship between perceptual evaluation and objective multiparametric evaluation of dysphonia severity. J Voice 2008; 22: 138-145
  • 35 Dejonckere P, Schoentgen J, Giordano A, Fraj S, Bocchi L, Manfredi C. Validity of jitter measures in non-quasi-periodic voices. Part I: perceptual and computer performances in cycle pattern recognition. Logoped Phoniatr Vocol 2011; 36: 70-77
  • 36 Werth K, Voigt D, Dollinger M, Eysholdt U, Lohscheller J. Clinical value of acoustic voice measures: a retrospective study. Eur Arch Otorhinolaryngol 2010; 267: 1261-1271
  • 37 Fleischer S, Hess M.. Systematischer Untersuchungsablauf bei der Videolaryngoskopie und Stroboskopie. HNO 2003; 51: 160-167
  • 38 Fleischer S, Hess M. Die Bedeutung der Stroboskopie in der laryngologischen Praxis. HNO 2006; 54: 628-634
  • 39 Boehme G, Gross M. Stroboscopy. Wiley; 2005
  • 40 Nawka T, Konerding U. The Interrater Reliability of Stroboscopy Evaluations. J Voice. 2012
  • 41 Derkay CS, Wiatrak B. Recurrent respiratory papillomatosis: a review. Laryngoscope 2008; 118: 1236-1247
  • 42 Dedo HH, Yu KC. CO(2) laser treatment in 244 patients with respiratory papillomas. Laryngoscope 2001; 111: 1639-1644
  • 43 Mau T. Diagnostic evaluation and management of hoarseness. Med Clin North Am 2010; 94: 945-960
  • 44 Steinberg BM, Topp WC, Schneider PS, Abramson AL. Laryngeal papillomavirus infection during clinical remission. N Engl J Med 1983; 308: 1261-1264
  • 45 Pasquale K, Wiatrak B, Woolley A, Lewis L. Microdebrider versus CO2 laser removal of recurrent respiratory papillomas: a prospective analysis. Laryngoscope 2003; 113: 139-143
  • 46 Zeitels SM, Casiano RR, Gardner GM, Hogikyan ND, Koufman JA, Rosen CA. Management of common voice problems: Committee report. Otolaryngol Head Neck Surg 2002; 126: 333-348
  • 47 Nawka T, Hosemann W. Surgical procedures for voice restoration. GMS Curr Top Otorhinolaryngol Head Neck Surg 2005; 4 Doc14
  • 48 Mortensen M, Woo P. An underreported complication of laryngeal microdebrider: vocal fold web and granuloma: a case report. Laryngoscope 2009; 119: 1848-1850
  • 49 Dikkers FG. Treatment of recurrent respiratory papillomatosis with microsurgery in combination with intralesional cidofovir – a prospective study. Eur Arch Otorhinolaryngol 2006; 263: 440-443
  • 50 Mikolajczak S, Quante G, Weissenborn S, Wafaisade A, Wieland U, Luers JC, Klussmann JP, Beutner D. The impact of cidofovir treatment on viral loads in adult recurrent respiratory papillomatosis. Eur Arch Otorhinolaryngol. 2012: 2543-2548
  • 51 Bielecki I, Mniszek J, Cofala M. Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children. Int J Pediatr Otorhinolaryngol 2009; 73: 681-684
  • 52 Waldfahrer F. Lokale Applikation von Cidofovir bei Larynxpapillomatose: aktuelle Hinweise und Warnungen. HNO Informationen 2011; 36: 156
  • 53 Gillen D. Direct healthcare professional communication regarding serious adverse reactions following off-label use of Vistide.[letter]. Vistide DHPC letter. http://wwwcbg-mebnl/NR/rdonlyres/FFB51936-EC22-4180-A213-9E907F06A774/011pdf 2011
  • 54 Donne AJ, Hampson L, He XT, Day PJ, Salway F, Rothera MP, Homer JJ, Hampson IN. Potential risk factors associated with the use of cidofovir to treat benign human papillomavirus-related disease. Antivir Ther 2009; 14: 939-952
  • 55 Man LX, Statham MM, Rosen CA. Mucosal bridge and pitting of the true vocal fold: an unusual complication of cidofovir injection. Ann Otol Rhinol Laryngol 2010; 119: 236-238
  • 56 Tjon Pian GiRE, Dietz A, Djukic V, Eckel HE, Friedrich G, Golusinski W, Hantzakos A, Lawson G, Remacle M, Rihkanen H, Dikkers FG. Treatment of recurrent respiratory papillomatosis and adverse reactions following off-label use of cidofovir (Vistide®). Eur Arch Otorhinolaryngol 2012; 269: 361-362
  • 57 Nagel S, Busch C, Blankenburg T, Schutte W. Behandlung der respiratorischen Papillomatose – Kasuistik zur systemischen Therapie mit Bevacizumab. Pneumologie 2009; 63: 387-389
  • 58 Zeitels SM, Lopez-Guerra G, Burns JA, Lutch M, Friedman AM, Hillman RE. Microlaryngoscopic and office-based injection of bevacizumab (Avastin) to enhance 532-nm pulsed KTP laser treatment of glottal papillomatosis. Ann Otol Rhinol Laryngol Suppl 2009; 201: 1-13
  • 59 Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE. Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study. Ann Otol Rhinol Laryngol 2011; 120: 627-634
  • 60 Forster G, Boltze C, Seidel J, Pawlita M, Muller A. Juvenile Larynxpapillomatose – Impfung mit dem polyvalenten Spaltimpfstoff Gardasil®. Laryngorhinootologie 2008; 87: 796-799
  • 61 Pawlita M, Gissmann L. Rekurrierende respiratorische Papillomatose Indikation für HPV-Vakzination?. Dtsch Med Wochenschr 2009; 134 (Suppl) S100-S102
  • 62 Goon P, Sonnex C, Jani P, Stanley M, Sudhoff H. Recurrent respiratory papillomatosis: an overview of current thinking and treatment. Eur Arch Otorhinolaryngol 2008; 265: 147-151
  • 63 Wallis L, Jackson-Menaldi C, Holland W, Giraldo A. Vocal fold nodule vs. vocal fold polyp: answer from surgical pathologist and voice pathologist point of view. J Voice 2004; 18: 125-129
  • 64 Martins RH, Defaveri J, Domingues MA, de Albuquerquee Silva R. Vocal polyps: clinical, morphological, and immunohistochemical aspects. J Voice 2011; 25: 98-106
  • 65 Thibeault SL, Merrill RM, Roy N, Gray SD, Smith EM. Occupational risk factors associated with voice disorders among teachers. Ann Epidemiol 2004; 14: 786-792
  • 66 Srirompotong S, Saeseow P, Vatanasapt P. Small vocal cord polyps: completely resolved with conservative treatment. Southeast Asian J Trop Med Public Health 2004; 35: 169-171
  • 67 Dworkin JP. Laryngitis: types, causes, and treatments. Otolaryngol Clin North Am 2008; 41: 419-436
  • 68 Branski RC, Saltman B, Sulica L, Szeto H, Duflo S, Felsen D, Kraus DH. Cigarette smoke and reactive oxygen species metabolism: implications for the pathophysiology of Reinke’s edema. Laryngoscope 2009; 119: 2014-2018
  • 69 Raabe J, Pascher W. Das Reinke-Ödem: Eine Untersuchung zu Fragen der Ätiologie, der Prognose und der Wirksamkeit therapeutischer Interventionen. Laryngorhinootologie 1999; 78: 97-102
  • 70 Zeitels SM, Hillman RE, Bunting GW, Vaughn T. Reinke’s edema: phonatory mechanisms and management strategies. Ann Otol Rhinol Laryngol 1997; 106: 533-543
  • 71 Allen J. Cause of vocal fold scar. Curr Opin Otolaryngol Head Neck Surg 2010; 18: 475-480
  • 72 Nawka T, Hosemann W. Gestörte Stimme. Chirurgische Verfahren. Laryngorhinootologie 2005; 84 (Suppl) S201-S212
  • 73 Martinez Arias A, Remacle M, Lawson G. Treatment of vocal fold scar by carbon dioxide laser and collagen injection: retrospective study on 12 patients. Eur Arch Otorhinolaryngol 2010; 267: 1409-1414
  • 74 Benninger MS, Alessi D, Archer S, Bastian R, Ford C, Koufman J, Sataloff RT, Spiegel JR, Woo P. Vocal fold scarring: current concepts and management. Otolaryngol Head Neck Surg 1996; 115: 474-482
  • 75 Sataloff RT, Hawkshaw MJ, Divi V, Heman-Ackah YD. Voice surgery. Otolaryngol Clin North Am 2007; 40: 1151-1183, ix
  • 76 Desloge RB, Zeitels SM. Endolaryngeal microsurgery at the anterior glottal commissure: controversies and observations. Ann Otol Rhinol Laryngol 2000; 109: 385-392
  • 77 Bouchayer M, Cornut G. Microsurgery for benign lesions of the vocal folds. Ear Nose Throat J 1988; 67 446–449, 452–454 456-464 passim
  • 78 Rosen CA, Gartner-Schmidt J, Hathaway B, Simpson CB, Postma GN, Courey M, Sataloff RT. A nomenclature paradigm for benign midmembranous vocal fold lesions. Laryngoscope 2012; 122: 1335-1341
  • 79 Mortensen M, Schaberg M, Woo P. Diagnostic contributions of videolaryngostroboscopy in the pediatric population. Arch Otolaryngol Head Neck Surg 2010; 136: 75-79
  • 80 Martins RH, Santana MF, Tavares EL. Vocal cysts: clinical, endoscopic, and surgical aspects. J Voice 2011; 25: 107-110
  • 81 Rosen CA, Murry T. Nomenclature of voice disorders and vocal pathology. Otolaryngol Clin North Am 2000; 33: 1035-1046
  • 82 Rubin AD, Gherson S, Sataloff RT. Vocal fold nodules. Ear Nose Throat J 2004; 83: 450
  • 83 Sataloff RT, Spiegel JR, Hawkshaw MJ. Strobovideolaryngoscopy: results and clinical value. Ann Otol Rhinol Laryngol 1991; 100: 725-727
  • 84 Smolander S, Huttunen K. Voice problems experienced by Finnish comprehensive school teachers and realization of occupational health care. Logoped Phoniatr Vocol 2006; 31: 166-171
  • 85 Martins RH, Defaveri J, Custodio Domingues MA, de Albuquerque ESR . Fabro A. Vocal fold nodules: morphological and immunohistochemical investigations. J Voice 2010; 24: 531-539
  • 86 Marcotullio D, Magliulo G, Pietrunti S, Suriano M. Exudative laryngeal diseases of Reinke’s space: a clinicohistopathological framing. J Otolaryngol 2002; 31: 376-380
  • 87 Dikkers FG, Nikkels PG. Lamina propria of the mucosa of benign lesions of the vocal folds. Laryngoscope 1999; 109: 1684-1689
  • 88 Behrman A, Rutledge J, Hembree A, Sheridan S. Vocal hygiene education, voice production therapy, and the role of patient adherence: a treatment effectiveness study in women with phonotrauma. J Speech Lang Hear Res 2008; 51: 350-366
  • 89 Leonard R. Voice therapy and vocal nodules in adults. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 453-457
  • 90 Holmberg EB, Hillman RE, Hammarberg B, Sodersten M, Doyle P. Efficacy of a behaviorally based voice therapy protocol for vocal nodules. J Voice 2001; 15: 395-412
  • 91 Pedersen M, McGlashan J. Surgical versus non-surgical interventions for vocal cord nodules. Cochrane Database Syst Rev 2012; 6: CD001934
  • 92 Benninger MS. Microdissection or microspot CO2 laser for limited vocal fold benign lesions: a prospective randomized trial. Laryngoscope 2000; 110: 1-17
  • 93 Benninger MS. Laser surgery for nodules and other benign laryngeal lesions. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 440-444
  • 94 Rosen CA, Lombard LE, Murry T. Acoustic, aerodynamic, and videostroboscopic features of bilateral vocal fold lesions. Ann Otol Rhinol Laryngol 2000; 109: 823-828
  • 95 Murano E, Hosako-Naito Y, Tayama N, Oka T, Miyaji M, Kumada M, Niimi S. Bamboo node: primary vocal fold lesion as evidence of autoimmune disease. J Voice 2001; 15: 441-450
  • 96 Hilgert E, Toleti B, Kruger K, Nejedlo I. Hoarseness due to bamboo nodes in patients with autoimmune diseases: a review of literature. J Voice 2008; 22: 343-350
  • 97 Immerman S, Sulica L. Bamboo nodes. Otolaryngol Head Neck Surg 2007; 137: 162-163
  • 98 Schwemmle C, Kreipe HH, Witte T, Ptok M. Bamboo nodes associated with mixed connective tissue disease as a cause of hoarseness. Rheumatol Int. 2011
  • 99 Storck C, Brockmann M, Zimmermann E, Nekahm-Heis D, Zorowka PG. Laryngeales Kontaktgranulom. HNO 2009; 57: 1075-1080
  • 100 Mans EJ, Kuhn AG, Lamprecht-Dinnesen A. Persönlichkeitsmerkmale von Patienten mit Kontaktgranulom. Laryngorhinootologie 1993; 72: 225-230
  • 101 Carroll TL, Gartner-Schmidt J, Statham MM, Rosen CA. Vocal process granuloma and glottal insufficiency: an overlooked etiology?. Laryngoscope 2010; 120: 114-120
  • 102 Devaney KO, Rinaldo A, Ferlito A. Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment. Oral Oncol 2005; 41: 666-669
  • 103 Benjamin B, Croxson G. Vocal cord granulomas. Ann Otol Rhinol Laryngol 1985; 94: 538-541
  • 104 Ylitalo R, Lindestad PA. A retrospective study of contact granuloma. Laryngoscope 1999; 109: 433-436
  • 105 Havas TE, Priestley J, Lowinger DS. A management strategy for vocal process granulomas. Laryngoscope 1999; 109: 301-306
  • 106 Sieron J, Johannsen HS. Das Kontaktgranulom: Symptomatik – Ätiologie – Diagnostik – Therapie. Laryngorhinootologie 1992; 71: 193-197
  • 107 Hoffman HT, Overholt E, Karnell M, McCulloch TM. Vocal process granuloma. Head Neck 2001; 23: 1061-1074
  • 108 Damrose EJ, Damrose JF. Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma. J Laryngol Otol 2008; 122: 824-828
  • 109 Mortensen M, Woo P. Office steroid injections of the larynx. Laryngoscope 2006; 116: 1735-1739
  • 110 Sun GB, Sun N, Tang HH, Zhu QB, Wen W, Zheng HL. Zinc sulfate therapy of vocal process granuloma. Eur Arch Otorhinolaryngol 2012; 269: 2087-2090
  • 111 Kiese-Himmel C, Kruse E. Ein Follow-up von Patienten mit laryngealem Kontaktgranulom. HNO 1997; 45: 389-395
  • 112 Santos PM, Afrassiabi A, Weymuller EAJ. Risk factors associated with prolonged intubation and laryngeal injury. Otolaryngol Head Neck Surg 1994; 111: 453-459
  • 113 Drosnes DL, Zwillenberg DA. Laryngeal granulomatous polyp after short-term intubation of a child. Ann Otol Rhinol Laryngol 1990; 99: 183-186
  • 114 Pontes P, De Biase N, Kyrillos L, Pontes A. Importance of glottic configuration in the development of posterior laryngeal granuloma. Ann Otol Rhinol Laryngol 2001; 110: 765-769
  • 115 Lemos EM, Sennes LU, Imamura R, Tsuji DH. Vocal process granuloma: clinical characterization, treatment and evolution. Braz J Otorhinolaryngol 2005; 71: 494-498
  • 116 Wang CP, Ko JY, Wang YH, Hu YL, Hsiao TY. Vocal process granuloma – A result of long-term observation in 53 patients. Oral Oncol 2009; 45: 821-825
  • 117 Martins RH, Goncalves TM, Neves DS, Fracalossi TA, Tavares EL, Moretti-Ferreira D. Sulcus vocalis: evidence for autosomal dominant inheritance. Genet Mol Res 2011; 10: 3163-3168
  • 118 Hansen JK, Thibeault SL. Current understanding and review of the literature: vocal fold scarring. J Voice 2006; 20: 110-120
  • 119 Branski RC, Verdolini K, Sandulache V, Rosen CA, Hebda PA. Vocal fold wound healing: a review for clinicians. J Voice 2006; 20: 432-442
  • 120 Yan Y, Olszewski AE, Hoffman MR, Zhuang P, Ford CN, Dailey SH, Jiang JJ. Use of lasers in laryngeal surgery. J Voice 2010; 24: 102-109
  • 121 Zeitels SM. Laser versus cold instruments for microlaryngoscopic surgery. Laryngoscope 1996; 106: 545-552
  • 122 Hormann K, Baker-Schreyer A, Keilmann A, Biermann G. Functional results after CO2 laser surgery compared with conventional phonosurgery. J Laryngol Otol 1999; 113: 140-144
  • 123 Schindler A, Palonta F, Preti G, Ottaviani F, Schindler O, Cavalot AL. Voice quality after carbon dioxide laser and conventional surgery for T1A glottic carcinoma. J Voice 2004; 18: 545-550
  • 124 Schwartz SR, Cohen SM, Dailey SH et al. Clinical practice guideline: hoarseness (dysphonia). Otolaryngol Head Neck Surg 2009; 141: S1-S31
  • 125 Johns MM, Garrett CG, Hwang J, Ossoff RH, Courey MS. Quality-of-life outcomes following laryngeal endoscopic surgery for non-neoplastic vocal fold lesions. Ann Otol Rhinol Laryngol 2004; 113: 597-601
  • 126 Mortensen M. Laryngeal steroid injection for vocal fold scar. Curr Opin Otolaryngol Head Neck Surg 2010; 18: 487-491
  • 127 Suehiro A, Hirano S, Kishimoto Y, Tateya I, Rousseau B, Ito J. Effects of basic fibroblast growth factor on rat vocal fold fibroblasts. Ann Otol Rhinol Laryngol 2010; 119: 690-696
  • 128 Welham NV, Dailey SH, Ford CN, Bless DM. Voice handicap evaluation of patients with pathologic sulcus vocalis. Ann Otol Rhinol Laryngol 2007; 116: 411-417
  • 129 Poels PJ, de Jong FI, Schutte HK. Consistency of the preoperative and intraoperative diagnosis of benign vocal fold lesions. J Voice 2003; 17: 425-433
  • 130 Dailey SH, Spanou K, Zeitels SM. The evaluation of benign glottic lesions: rigid telescopic stroboscopy versus suspension microlaryngoscopy. J Voice 2007; 21: 112-118
  • 131 Dailey SH, Ford CN. Surgical management of sulcus vocalis and vocal fold scarring. Otolaryngol Clin North Am 2006; 39: 23-42
  • 132 Rosen CA. Vocal fold scar: evaluation and treatment. Otolaryngol Clin North Am 2000; 33: 1081-1086
  • 133 Su CY, Tsai SS, Chiu JF, Cheng CA. Medialization laryngoplasty with strap muscle transposition for vocal fold atrophy with or without sulcus vocalis. Laryngoscope 2004; 114: 1106-1112
  • 134 Welham NV, Choi SH, Dailey SH, Ford CN, Jiang JJ, Bless DM. Prospective multi-arm evaluation of surgical treatments for vocal fold scar and pathologic sulcus vocalis. Laryngoscope 2011; 121: 1252-1260
  • 135 Sataloff RT. Autologous fat implantation for vocal fold scar. Curr Opin Otolaryngol Head Neck Surg 2010; 18: 503-506
  • 136 Sataloff RT, Spiegel JR, Hawkshaw M, Rosen DC, Heuer RJ. Autologous fat implantation for vocal fold scar: a preliminary report. J Voice 1997; 11: 238-246
  • 137 Neuenschwander MC, Sataloff RT, Abaza MM, Hawkshaw MJ, Reiter D, Spiegel JR. Management of vocal fold scar with autologous fat implantation: perceptual results. J Voice 2001; 15: 295-304
  • 138 Hertegard S, Hallen L, Laurent C, Lindstrom E, Olofsson K, Testad P, Dahlqvist A. Cross-linked hyaluronan versus collagen for injection treatment of glottal insufficiency: 2-year follow-up. Acta Otolaryngol 2004; 124: 1208-1214
  • 139 Svensson B, Nagubothu SR, Cedervall J, Chan RW, Le Blanc K, Kimura M, Ahrlund-Richter L, Tolf A, Hertegard S. Injection of human mesenchymal stem cells improves healing of vocal folds after scar excision – a xenograft analysis. Laryngoscope 2011; 121: 2185-2190
  • 140 Kishimoto Y, Welham NV, Hirano S. Implantation of atelocollagen sheet for vocal fold scar. Curr Opin Otolaryngol Head Neck Surg 2010; 18: 507-511
  • 141 Suehiro A, Hirano S, Kishimoto Y, Rousseau B, Nakamura T, Ito J. Treatment of acute vocal fold scar with local injection of basic fibroblast growth factor: a canine study. Acta Otolaryngol 2010; 130: 844-850
  • 142 Chhetri DK, Mendelsohn AH. Hyaluronic acid for the treatment of vocal fold scars. Curr Opin Otolaryngol Head Neck Surg 2010; 18: 498-502
  • 143 Mortensen MM, Woo P, Ivey C, Thompson C, Carroll L, Altman K. The use of the pulse dye laser in the treatment of vocal fold scar: a preliminary study. Laryngoscope 2008; 118: 1884-1888
  • 144 Welham NV, Rousseau B, Ford CN, Bless DM. Tracking outcomes after phonosurgery for sulcus vocalis: a case report. J Voice 2003; 17: 571-578
  • 145 Behrman A, Sulica L. Voice rest after microlaryngoscopy: current opinion and practice. Laryngoscope 2003; 113: 2182-2186
  • 146 Ishikawa K, Thibeault S. Voice rest versus exercise: a review of the literature. J Voice 2010; 24: 379-387
  • 147 Emerich KA, Spiegel JR, Sataloff RT. Phonomicrosurgery III: pre- and postoperative care. Otolaryngol Clin North Am 2000; 33: 1071-1080
  • 148 Rousseau B, Cohen SM, Zeller AS, Scearce L, Tritter AG, Garrett CG. Compliance and quality of life in patients on prescribed voice rest. Otolaryngol Head Neck Surg 2011; 144: 104-107
  • 149 Nawka T. Postoperative Betreuung in der operativen Laryngologie. HNO 2008; 56: 1183-1189
  • 150 Richter B, Echternach M. Stimmdiagnostik und -therapie bei Angehörigen stimmintensiver Berufe. HNO 2010; 58: 389-398
  • 151 Richter B, Echternach M. Stimmärztliche Betreuung und Behandlung von Sängern. HNO 2011; 59: 547-555
  • 152 Brunner E, Friedrich G, Kiesler K, Chibidziura-Priesching J, Gugatschka M. Subjective breathing impairment in unilateral vocal fold paralysis. Folia Phoniatr Logop 2011; 63: 142-146
  • 153 Misono S, Merati AL. Evidence-based practice: evaluation and management of unilateral vocal fold paralysis. Otolaryngol Clin North Am 2012; 45: 1083-1108
  • 154 Apfelbaum RI, Kriskovich MD, Haller JR. On the incidence, cause, and prevention of recurrent laryngeal nerve palsies during anterior cervical spine surgery. Spine (Phila Pa 1976). 2000 25. 2906-2912
  • 155 Bergamaschi R, Becouarn G, Ronceray J, Arnaud JP. Morbidity of thyroid surgery. Am J Surg 1998; 176: 71-75
  • 156 Chiang FY, Wang LF, Huang YF, Lee KW, Kuo WR. Recurrent laryngeal nerve palsy after thyroidectomy with routine identification of the recurrent laryngeal nerve. Surgery 2005; 137: 342-347
  • 157 Sulica L. The natural history of idiopathic unilateral vocal fold paralysis: evidence and problems. Laryngoscope 2008; 118: 1303-1307
  • 158 Leder SB, Ross DA. Incidence of vocal fold immobility in patients with dysphagia. Dysphagia 2005; 20: 163-167 discussion 168–169
  • 159 Harries ML, Morrison M. The role of stroboscopy in the management of a patient with a unilateral vocal fold paralysis. J Laryngol Otol 1996; 110: 141-143
  • 160 Eysholdt U, Lohscheller J. Phonovibrogramm: Stimmlippendynamik in einem Bild. HNO 2008; 56: 1207-1212
  • 161 Crumley RL. Laryngeal synkinesis: its significance to the laryngologist. Ann Otol Rhinol Laryngol 1989; 98: 87-92
  • 162 Woodson GE. Configuration of the glottis in laryngeal paralysis. I: Clinical study. Laryngoscope 1993; 103: 1227-1234
  • 163 Sulica L, Myssiorek D. Vocal fold paralysis. Otolaryngol Clin North Am 2004; 37: xi-xiv
  • 164 Wang CP, Chen TC, Lou PJ, Yang TL, Hu YL, Shieh MJ, Ko JY, Hsiao TY. Neck ultrasonography for the evaluation of the etiology of adult unilateral vocal fold paralysis. Head Neck 2012; 34: 643-648
  • 165 El Badawey MR, Punekar S, Zammit-Maempel I. Prospective study to assess vocal cord palsy investigations. Otolaryngol Head Neck Surg 2008; 138: 788-790
  • 166 Merati AL, Halum SL, Smith TL. Diagnostic testing for vocal fold paralysis: survey of practice and evidence-based medicine review. Laryngoscope 2006; 116: 1539-1552
  • 167 Rickert SM, Childs LF, Carey BT, Murry T, Sulica L. Laryngeal electromyography for prognosis of vocal fold palsy: a meta-analysis. Laryngoscope 2012; 122: 158-161
  • 168 Crumley RL. Laryngeal synkinesis revisited. Ann Otol Rhinol Laryngol 2000; 109: 365-371
  • 169 Woo P, Arandia H. Intraoperative laryngeal electromyographic assessment of patients with immobile vocal fold. Ann Otol Rhinol Laryngol 1992; 101: 799-806
  • 170 Rubin AD, Hawkshaw MJ, Moyer CA, Dean CM, Sataloff RT. Arytenoid cartilage dislocation: a 20-year experience. J Voice 2005; 19: 687-701
  • 171 Rieger A, Hass I, Gross M, Gramm HJ, Eyrich K. Intubationstraumen des Larynx – eine Literaturübersicht unter besonderer Berücksichtigung der Aryknorpelluxation. Anasthesiol Intensivmed Notfallmed Schmerzther 1996; 31: 281-287
  • 172 Norris BK, Schweinfurth JM. Arytenoid dislocation: An analysis of the contemporary literature. Laryngoscope 2011; 121: 142-146
  • 173 Miller S. Voice therapy for vocal fold paralysis. Otolaryngol Clin North Am 2004; 37: 105-119
  • 174 Schuster M, Eysholdt U. Therapie der einseitigen Stimmlippenparese. HNO 2005; 53: 756-765
  • 175 Isshiki N. Mechanical and dynamic aspects of voice production as related to voice therapy and phonosurgery. J Voice 1998; 12: 125-137
  • 176 Mattioli F, Bergamini G, Alicandri-Ciufelli M, Molteni G, Luppi MP, Nizzoli F, Grammatica A, Presutti L. The role of early voice therapy in the incidence of motility recovery in unilateral vocal fold paralysis. Logoped Phoniatr Vocol 2011; 36: 40-47
  • 177 Hazlett DE, Duffy OM, Moorhead SA. Review of the impact of voice training on the vocal quality of professional voice users: implications for vocal health and recommendations for further research. J Voice 2011; 25: 181-191
  • 178 Kelchner LN, Lee L, Stemple JC. Laryngeal function and vocal fatigue after prolonged reading in individuals with unilateral vocal fold paralysis. J Voice 2003; 17: 513-528
  • 179 Ptok M, Strack D. Klassische Stimmtherapie versus Elektrostimulationstherapie bei Patienten mit einseitiger Rekurrensparese. HNO 2005; 53: 1092-1097
  • 180 Ptok M, Strack D. Electrical stimulation-supported voice exercises are superior to voice exercise therapy alone in patients with unilateral recurrent laryngeal nerve paresis: results from a prospective, randomized clinical trial. Muscle Nerve 2008; 38: 1005-1011
  • 181 Ptok M, Strack D. Therapeutische Beeinflussung von Schwingungsirregularitäten durch Elektrostimulationstherapie. HNO 2009; 57: 1157-1162
  • 182 Rosen CA, Statham MM. Vocal fold injection as a treatment for glottic insufficiency: pro. Arch Otolaryngol Head Neck Surg 2010; 136: 825-827
  • 183 Chang JI, Bevans SE, Schwartz SR. Otolaryngology clinic of North America: evidence-based practice: management of hoarseness/dysphonia. Otolaryngol Clin North Am 2012; 45: 1109-1126
  • 184 Carroll TL, Rosen CA. Trial vocal fold injection. J Voice 2010; 24: 494-498
  • 185 Friedman AD, Burns JA, Heaton JT, Zeitels SM. Early versus late injection medialization for unilateral vocal cord paralysis. Laryngoscope 2010; 120: 2042-2046
  • 186 Graboyes EM, Bradley JP, Meyers BF, Nussenbaum B. Efficacy and safety of acute injection laryngoplasty for vocal cord paralysis following thoracic surgery. Laryngoscope 2011; 121: 2406-2410
  • 187 Sittel C, Bosch N, Plinkert PK. Operative Stimmrehabilitation bei einseitiger Lähmung des N.laryngeus inferior (recurrens). Chirurg 2008; 79: 1055-1064
  • 188 Friedrich G. Externe Stimmlippenmedialisation: Funktionelle Ergebnisse. Laryngorhinootologie 1998; 77: 18-26
  • 189 Friedrich G. Externe Stimmlippenmedialisation: Operative Erfahrungen und Modifikationen. Laryngorhinootologie 1998; 77: 7-17
  • 190 Friedrich G, de Jong FI, Mahieu HF, Benninger MS, Isshiki N. Laryngeal framework surgery: a proposal for classification and nomenclature by the Phonosurgery Committee of the European Laryngological Society. Eur Arch Otorhinolaryngol 2001; 258: 389-396
  • 191 Sittel C. Larynx: Implantate und Stents. Laryngorhinootologie 2009; 88 (Suppl) S119-S124
  • 192 Morgan JE, Zraick RI, Griffin AW, Bowen TL, Johnson FL. Injection versus medialization laryngoplasty for the treatment of unilateral vocal fold paralysis. Laryngoscope 2007; 117: 2068-2074
  • 193 Vinson KN, Zraick RI, Ragland FJ. Injection versus medialization laryngoplasty for the treatment of unilateral vocal fold paralysis: follow-up at six months. Laryngoscope 2010; 120: 1802-1807
  • 194 O’Leary MA, Grillone GA. Injection laryngoplasty. Otolaryngol Clin North Am 2006; 39: 43-54
  • 195 Zeitels SM, Hochman I, Hillman RE. Adduction arytenopexy: a new procedure for paralytic dysphonia with implications for implant medialization. Ann Otol Rhinol Laryngol Suppl 1998; 173: 2-24
  • 196 Zeitels SM, Mauri M, Dailey SH. Adduction arytenopexy for vocal fold paralysis: indications and technique. J Laryngol Otol 2004; 118: 508-516
  • 197 Mallur PS, Rosen CA. Vocal fold injection: review of indications, techniques, and materials for augmentation. Clin Exp Otorhinolaryngol 2010; 3: 177-182
  • 198 Amin MR. Thyrohyoid approach for vocal fold augmentation. Ann Otol Rhinol Laryngol 2006; 115: 699-702
  • 199 Trask DK, Shellenberger DL, Hoffman HT. Transnasal, endoscopic vocal fold augmentation. Laryngoscope 2005; 115: 2262-2265
  • 200 Sulica L, Rosen CA, Postma GN, Simpson B, Amin M, Courey M, Merati A. Current practice in injection augmentation of the vocal folds: indications, treatment principles, techniques, and complications. Laryngoscope 2010; 120: 319-325
  • 201 Young VN, Zullo TG, Rosen CA. Analysis of laryngeal framework surgery: 10-year follow-up to a national survey. Laryngoscope 2010; 120: 1602-1608