Neuropediatrics 2013; 44(05): 265-267
DOI: 10.1055/s-0033-1333873
Short Communication
Georg Thieme Verlag KG Stuttgart · New York

Association of Acute Cerebellar Ataxia and Human Papilloma Virus Vaccination: A Case Report

Chihiro Yonee
1  Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, Japan
,
Mitsuo Toyoshima
1  Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, Japan
,
Yoshihiro Maegaki
2  Division of Child Neurology, Institute of Neurological Science, Tottori University Faculty of Medicine, Yonago City, Tottori, Japan
,
Yuichi Kodama
1  Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, Japan
,
Hiroshi Hayami
3  Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, Japan
,
Yukitoshi Takahashi
4  Department of Pediatrics, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka City, Shizuoka, Japan
,
Susumu Kusunoki
5  Department of Neurology, School of Medicine, Kinki University, Sayama City, Osaka, Japan
,
Ayumi Uchibori
6  Department of Neurology, School of Medicine, Kyorin University, Mitaka City, Tokyo, Japan
,
Atsuro Chiba
6  Department of Neurology, School of Medicine, Kyorin University, Mitaka City, Tokyo, Japan
,
Yoshifumi Kawano
1  Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, Japan
› Author Affiliations
Further Information

Publication History

22 August 2012

02 January 2013

Publication Date:
01 February 2013 (online)

Abstract

Introduction We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine.

Patient and Method This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular rhythm, 12 days after administration of the HPV-16/18 AS04-adjuvanted cervical cancer vaccine. After this, the patient received methylprednisolone pulse and intravenous immunoglobulin (IVIG) therapies as well as immunoadsorption plasmapheresis.

Results Severe ACA symptoms did not improve after methylprednisolone pulse and IVIG therapies, but the patient recovered completely after immunoadsorption plasmapheresis.

Conclusion This temporal association strongly suggests that ACA was induced by the vaccination.