Exp Clin Endocrinol Diabetes 2013; 121(06): 329-333
DOI: 10.1055/s-0033-1334883
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Elevated Undercarboxylated and Reduced Carboxylated Osteocalcin are Associated with Metabolic Syndrome in Middle Age Asian Females

J.-J. Liu*
1   Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore
,
W. C. Toy*
1   Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore
,
M.D. S. Wong
1   Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore
,
C.S. H. Tan
1   Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore
,
S. Tavintharan
3   Department of Medicine, Khoo Teck Puat Hospital, Republic of Singapore
,
M. S. Wong
2   Department of Laboratory Medicine, Khoo Teck Puat Hospital, Republic of Singapore
,
C. F. Sum
3   Department of Medicine, Khoo Teck Puat Hospital, Republic of Singapore
,
S. C. Lim
1   Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore
3   Department of Medicine, Khoo Teck Puat Hospital, Republic of Singapore
› Author Affiliations
Further Information

Publication History

received 18 September 2012
first decision 23 December 2012

accepted 31 January 2013

Publication Date:
19 March 2013 (online)

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Abstract

Objective:

Accumulating data suggest that bone plays a role in energy metabolism through decarboxylation of osteocalcin. Thus, we aimed to study the association of circulating under-­carboxylated osteocalcin (UC-OCN) and car­boxylated osteocalcin (C-OCN) with metabolic syndrome in middle aged Asian population.

Subjects and Methods:

In this cross-sectional study, 131 middle aged Asian subjects were recruited. Circulating UC-OCN, C-OCN and parameters of metabolic phenotype were measured.

Results:

Circulating UC-OCN was increased in subjects with metabolic syndrome (8.1±7.2 ng/ml vs. 5.9±4.6 ng/ml, p=0.036). In contrast, C-OCN showed a non-significant trend towards reduction in subjects with metabolic syndrome (3.6±2.2 ng/ml vs. 4.3±1.8 ng/ml, p=0.057). Further analysis revealed that changes in both UC-OCN and C-OCN occurred primarily among females with metabolic syndrome. Interestingly, neither forms of OCN differed significantly between individuals with and without metabolic syndrome in males. Logistic regression revealed that UC-OCN was independently associated with metabolic syndrome after adjusting for multiple covariates. However, association between metabolic syndrome and C-OCN was dependent on gender (i. e., amongst females only) in the fully adjusted regression model.

Conclusions:

Variation in OCN (including its sub-species) was associated with variation in metabolic parameters amongst Asian adults. Circulating UC-OCN was increased while C-OCN was decreased in treatment-naïve females with metabolic syndrome. Our preliminary observations further supported a potential link between bone and energy metabolism in humans.

*

* Equal contributors to the manuscript.