p-Toluenesulfonic Acid Catalyzed One-Pot Synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-one Derivatives

Wenjie Liu; Shaohua Wang; Haiying Zhan; Mingshan Li

doi:10.1055/s-0033-1339012

Synlett, Inhaltsverzeichnis

Synlett 2014; 25(10): 1478-1481
DOI: 10.1055/s-0033-1339012

letter

p-Toluenesulfonic Acid Catalyzed One-Pot Synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-one Derivatives

Autoren

Wenjie Liu

School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. of China Fax: +86(760)88207939 eMail: wangshaohua108@163.com
Shaohua Wang*

School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. of China Fax: +86(760)88207939 eMail: wangshaohua108@163.com
Haiying Zhan

School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. of China Fax: +86(760)88207939 eMail: wangshaohua108@163.com
Mingshan Li

School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. of China Fax: +86(760)88207939 eMail: wangshaohua108@163.com

Abstract

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Abstract

A novel one-pot protocol has been developed for the construction of alkenylated 4H-pyrido[1,2-a]pyrimidin-4-one derivatives from 2-aminopyridine in the presence of PTSA. The present approach opens a new way for the formation of C–C and C–N bonds under mild conditions.

Key words

metal-free - 4H-pyrido[1,2-a]pyrimidin-4-ones - PTSA - 2-aminopyridine - multicomponent reactions

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Referenzen

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Zusatzmaterial

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