Exp Clin Endocrinol Diabetes 2013; 121(08): 475-482
DOI: 10.1055/s-0033-1343395
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Endurance Exercise Alters Cellular Immune Status and Resistin Concentrations in Men Suffering from Non-insulin-dependent Type 2 Diabetes

P. Wenning
1   Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
,
T. Kreutz
1   Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
,
A. Schmidt
1   Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
,
D. Opitz
1   Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
,
C. Graf
2   Institute for Movement and Neurosciences, German Sport University Cologne, Cologne, Germany
,
S. Voss
3   Center for Preventive Doping Research/Institute of Biochemistry, German Sport University Cologne, Germany
4   Anti-Doping Lab Qatar, Doha, Qatar
,
W. Bloch
1   Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
,
K. Brixius
1   Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany
› Author Affiliations
Further Information

Publication History

received 28 December 2012
first decision 14 March 2013

accepted 20 March 2013

Publication Date:
11 September 2013 (online)

Abstract

It has been demonstrated that alterations of adipocytokines can alter immune status in type 2 diabetes. The present study investigated changes of adipocytokine plasma concentrations and cellular immune status in overweight men, suffering from non-insulin dependent type 2 diabetes (n=14, age 61.0±8.7 years, BMI 31.1±3.5 kg/cm2). Subjects underwent a 3 months endurance exercise intervention (twice per week for up to 45 min) cycling at a heart rate corresponding to a 2 mmol/l lactate threshold. Before and after the intervention testing for adipocytokines (leptin, adiponectin, resistin) and cellular immune status (including T memory-cells and regulative T-cells) was performed by RIA and FACS accordingly.

The exercise intervention improved anthropometric and metabolic parameters of all subjects. We observed a significant decline for resistin and for the CD19+ B-cells. The CD4+CD25+CD127low Treg-cells decreased, however not statistically significant. All other parameters remained unchanged.

In conclusion, even though only training twice a week, the exercise affected parts of the cellular immune system as well as resistin levels in men suffering from non-insulin dependent type 2 diabetes.