Aktuelle Dermatologie 2013; 39(12): 499-503
DOI: 10.1055/s-0033-1344980
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Protektiver Effekt von Betulin-Emulsionen

Protective Effect of Betulin-Emulsions
C. Adomat
1   Birken AG, Niefern-Öschelbronn
,
W. Gehring
2   Hautklinik am Klinikum der Stadt Karlsruhe
› Author Affiliations
Further Information

Publication History

Publication Date:
05 November 2013 (online)

Zusammenfassung

In zwei voneinander unabhängigen Studien wurde die protektive Wirkung von Betulin-Emulsionen allein (Imlan®-Creme Pur und Imlan®-Creme Plus, Birken AG, Niefern-Öschelbronn, Deutschland) und im Vergleich zu dem Hautschutz-Produkt Excipial Protect® (Spirig Pharma AG, Egerkingen, Schweiz) im repetitiven Waschtest mit Natriumlaurylsulfat (SLS) untersucht. Dabei konnte für alle Präparate eine vergleichbare Schutzwirkung gegenüber SLS nachgewiesen werden.

Abstract

In two independent studies the protective effect of two betulin-emulsions (Imlan® Creme Pur und Imlan® Creme Plus, Birken AG, Niefern-Öschelbronn, Germany) and of a betulin-emulsion in comparison to the skin protection creme Excipial Protect® was tested in a repetitive washing test with sodium dodecylsulfate (SLS). The effect concerning protection against SLS was found to be comparable for all three products.

 
  • Literatur

  • 1 Laszczyk M, Jäger S, Simon-Haarhaus B et al. Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (betulae cortex). Planta Med 2006; 72: 1389-1395
  • 2 Daniels R, Laszczyk MN. Betulin für tensidfreie Emulsionen. Pharmazeutische Zeitungen 2008; 11: 34-36
  • 3 Brandner JM, Zacheja S, Houdek P et al. Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model. Diabetes Care 2008; 31: 114-120
  • 4 Sultana N, Saify ZS. Naturally occurring and synthetic agents as potential anti-inflammatory and immunomodulants. Antiinflamm Antiallergy Agents Med Chem 2012; 11: 3-19
  • 5 Dikstein S, Katz M, Zlotogorski A et al. Comparison of different instruments for measuring stratum corneum moisture content. Int J Cosmet Sci 1986; 8: 289-292
  • 6 van der Valk PG, Nater JP, Bleumink E. Skin irritancy of surfactants as assessed by water vapor loss measurements. J Invest Dermatol 1984; 82: 291-293
  • 7 Nilsson GE. Measurement of water exchange through skin. Med Biol Eng Comput 1977; 15: 209-218
  • 8 Bircher A, de Boer EM, Agner T et al. Guidelines for measurement of cutaneous blood flow by laser Doppler flowmetry. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis 1994; 30: 65-72
  • 9 Diepgen TL, Coenraads PJ. The epidemiology of occupational contact dermatitis. Int Arch Occup Environ Health 1999; 72: 496-506
  • 10 Gloor M, Gehring W. Eigenwirkungen von Emulsionen auf die Hornschichtbarriere und -hydratation. Der Hautarzt 2003; 4: 324-330
  • 11 Gloor M, Hauth A, Gehring W. O/W emulsions compromise the stratum corneum barrier and improve drug penetration. Pharmazie 2003; 58: 709-715
  • 12 Laszczyk MN, Reitenbach-Blindt I, Gehring W. Regenerative und anti-entzündliche Effekte von Betulin-Emulsionen bei gestörter epidermaler Barrierefunktion. Akt Dermatol 2009; 35: 1-5
  • 13 Bani S, Kaul A, Khan B et al. Suppression of T lymphocyte activity by lupeol isolated from Crataeva religiosa. Phytother Res 2006; 20: 279-287
  • 14 Marquez-Martin A, De La Puerta R, Fernandez-Arche A et al. Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells. Cytokine 2006; 36: 211-217
  • 15 Braca A, Dal Piaz F, Marzocco S et al. Triterpene derivatives as inhibitors of protein involved in the inflammatory process: molecules interfering with phospholipase A2, cycloxygenase, and lipoxygenase. Curr Drug Targets 2011; 12: 302-321