2-(2-Phenylethyl)chromone Derivatives in Chinese Agarwood “Qi-Nan”
                    from Aquilaria sinensis

De Lan Yang; Wen Li Mei; Yan Bo Zeng; Zhi Kai Guo; You Xing Zhao; Hao Wang; Wen Jian Zuo; Wen Hua Dong; Qing Huang Wang; Hao Fu Dai

doi:10.1055/s-0033-1350647

Planta Medica, Table of Contents

Planta Med 2013; 79(14): 1329-1334
DOI: 10.1055/s-0033-1350647

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

2-(2-Phenylethyl)chromone Derivatives in Chinese Agarwood “Qi-Nan” from Aquilaria sinensis

Authors

De Lan Yang

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

³Horticultural and Garden College, Hainan University, Haikou, China
Wen Li Mei

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Yan Bo Zeng

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Zhi Kai Guo

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
You Xing Zhao

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Hao Wang

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Wen Jian Zuo

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Wen Hua Dong

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Qing Huang Wang

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Hao Fu Dai

¹Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

²National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

Abstract

Five new 2-(2-phenylethyl)chromone derivatives, qinanones A−E (1–5), together with eight known 2-(2-phenylethyl)chromone derivatives (6–13), were isolated from the Et₂O extract of high-quality Chinese agarwood “Qi-Nan” originating from Aquilaria sinensis. The structures of the new 2-(2-phenylethyl)chromones were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. In the bioassay for acetylcholinesterase inhibitors, compounds 1–6, 10, and 12 exhibited weak inhibitory activities (inhibition percentage ranged from 10 % to 24 % at the concentration of 50 µg/mL). Compared with other agarwoods, “Qi-Nan” was different in containing 2-(2-phenylethyl)chromones with unsubstituted chromone rings.

Key words

Aquilaria sinensis - Thymelaeaceae - Qi-Nan - 2-(2-phenylethyl)chromone derivatives - AChE inhibitory activities

Full Text

References

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