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Planta Med 2013; 79(14): 1329-1334
DOI: 10.1055/s-0033-1350647
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

2-(2-Phenylethyl)chromone Derivatives in Chinese Agarwood “Qi-Nan” from Aquilaria sinensis

De Lan Yang
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
3   Horticultural and Garden College, Hainan University, Haikou, China
,
Wen Li Mei
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
Yan Bo Zeng
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
Zhi Kai Guo
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
You Xing Zhao
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
Hao Wang
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
Wen Jian Zuo
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
Wen Hua Dong
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
Qing Huang Wang
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
,
Hao Fu Dai
1   Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
2   National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
› Author Affiliations
Further Information

Publication History

received 21 March 2013
revised 19 June 2013

accepted 25 June 2013

Publication Date:
08 August 2013 (online)

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Abstract

Five new 2-(2-phenylethyl)chromone derivatives, qinanones A−E (1–5), together with eight known 2-(2-phenylethyl)chromone derivatives (6–13), were isolated from the Et2O extract of high-quality Chinese agarwood “Qi-Nan” originating from Aquilaria sinensis. The structures of the new 2-(2-phenylethyl)chromones were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. In the bioassay for acetylcholinesterase inhibitors, compounds 1–6, 10, and 12 exhibited weak inhibitory activities (inhibition percentage ranged from 10 % to 24 % at the concentration of 50 µg/mL). Compared with other agarwoods, “Qi-Nan” was different in containing 2-(2-phenylethyl)chromones with unsubstituted chromone rings.

Key words

Aquilaria sinensis - Thymelaeaceae - Qi-Nan - 2-(2-phenylethyl)chromone derivatives - AChE inhibitory activities

Supporting Information

 

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