Thorac Cardiovasc Surg 2013; 61 - V36
DOI: 10.1055/s-0033-1354464

Assessment of Pressure Volume Relation under Various Pharmacological Conditions Using Mini-Pressure Wire and 3D-Echocardiography – Comparative Study with Conductance Technology in Piglets

U Herberg 1, D Ladage 2, K Linden 1, M Seehase 1, D Dürr 3, O Dewald 3, J Breuer 1
  • 1Pediatric Cardiology, University of Bonn, Bonn, Germany
  • 2Cardiology, University of Cologne, Germany
  • 3Cardiac Surgery, University of Bonn, Bonn, Germany

Introduction: Pressure-volume relations (PVR) provide vital information regarding cardiac pathophysiology and function. In children, acquiring PVR by conductance technology (CondT) is, due to catheter size, restricted to older age. The aim of the study was to assess the feasibility and accuracy of PVR – calculated from 3D volume data and simultaneously obtained pressure data by mini-pressure wire (Fig. 1) – and to compare the results with conductance technology.

Fig. 1: 3D PV loop.

Methods: In 14 piglets (weight: 4.1 – 7.0, mean: 6.1 kg), dp/dt max, dp/dt min, systolic myocardial elastance Ees, diastolic relaxation constant Tau, and end-diastolic PVR were determined under various conditions: baseline, epinephrine, and esmolol infusion.

Results: Computation of PVR was feasible, reproducible, and comparable with results obtained by conductance technology (Table 1).

– Table 1: 3D-Echo compared to conductance catheter

Mean ± SD

Baseline

Epinephrine

Esmolol

Ees (mm Hg)

3DE

1.3 ± 0.4

1.7 ± 0.4

1.0 ± 0.29

CondT

2.0 ± 0.7

2.7 ± 0.76

1.6 ± 0.27

Tau (ms)

3DE

18.6 ± 2.8

23.9 ± 7.6

25.0 ± 4.5

CondT

25.07 ± 4.5

25.0 ± 5.4

31.3 ± 10.8

Conclusions: Calculation of PVR from 3DE volume curves is a feasible method to assess different conditions of cardiac function in small hearts.