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Z Gastroenterol 2013; 51(12): 1389-1394
DOI: 10.1055/s-0033-1355518
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Mikroskopische Kolitis – neue praxisrelevante Erkenntnisse

Microscopic Colitis – New Insights Relevant to Clinical Practice
S. Miehlke
1   Facharztzentrum Eppendorf, Magen-Darm-Zentrum, Hamburg
,
D. Aust
2   Universitätsklinikum, Institut für Pathologie, Dresden
,
A. Madisch
3   Klinikum Siloah, Medizinische Klinik I, Hannover
› Author Affiliations
Further Information

Publication History

21 June 2013

27 August 2013

Publication Date:
21 October 2013 (online)

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Zusammenfassung

Die mikroskopische Kolitis ist eine zunehmend häufig diagnostizierte, chronisch-entzündliche Darmerkrankung, die nahezu regelhaft mit wässriger, nicht blutiger Diarrhö einhergeht und darüber hinaus zu Bauchschmerzen, nächtlicher Diarrhö, imperativem Stuhldrang und Inkontinenz führen kann. Histologisch werden traditionell die kollagene und die lymphozytäre Kolitis unterschieden. Eine neue dritte Subgruppe ist die sog. inkomplette mikroskopische Kolitis, die sich klinisch nicht von den anderen Formen unterscheidet. Budesonid ist derzeit die einzige evidenzbasierte, effektive Therapie, allerdings sind viele Probleme im therapeutischen Langzeitmangement noch ungelöst. Die vorliegende Arbeit gibt einen aktuellen Überblick über neue, praxisrelevante Entwicklungen auf dem Gebiet der mikroskopischen Kolitis.

Abstract

Microscopic colitis is an increasingly recognised chronic inflammatory bowel disease associated with watery, non-bloody diarrhoea. In addition, many patients suffer from abdominal pain, nocturnal diarrhoea, urgency and incontinence. The two traditional histological subtypes are collagenous colitis and lymphocytic colitis. A novel third subgroup is the so-called incomplete microscopic colitis which is clinically indistinguishable. At present, budesonide is the only evidenced-based effective therapy, however many problems in the long-term treatment strategy are still unsolved. The present paper reviews new developments in microscopic colitis which are relevant for clinical practice.

Schlüsselwörter

kollagene Kolitis - chronisch-entzündliche Darmerkrankung - colon irritabile

Key words

collagenous colitis - chronic inflammatory bowel disease - irritable colon
 

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