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Z Gastroenterol 2014; 52(2): 200-203
DOI: 10.1055/s-0033-1356439
Kasuistik
© Georg Thieme Verlag KG Stuttgart · New York

FOLFIRINOX as First-Line Treatment for Unresectable Acinar Cell Carcinoma of the Pancreas: A Case Report

FOLFIRINOX als Erstlinientherapie beim inoperablen Azinuszellkarzinom des Pankreas: Ein Fallbericht
U. Schempf
1   Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
,
B. Sipos
2   Institute of Pathology, University of Tuebingen, Tuebingen, Germany
,
C. König
3   Department for Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany
,
N. P. Malek
1   Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
,
M. Bitzer
1   Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
,
R. R. Plentz
1   Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
› Author Affiliations
Further Information

Publication History

08 June 2013

19 December 2013

Publication Date:
13 February 2014 (online)

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Abstract

Pancreatic acinar cell carcinoma (ACC) is a rare, aggressive variant of pancreatic ductal adenocarcinoma. Surgery is the only curative treatment option and protocols for palliative chemotherapies in this context are not standardized yet. We reported a 63-year-old white male patient who had painless jaundice, weight loss, elevated bilirubin, and a mass of the pancreatic head as well as liver metastasis. Core biopsy revealed the diagnosis of ACC. Therapy with FOLFIRINOX resulted in a significant decrease of the primary tumor and regressiveness of a liver metastasis after chemotherapy. Our report suggests that pancreatic ACC treated by FOLFIRINOX is well tolerated and might be superior to other single chemotherapies in this rare tumor disease.

Zusammenfassung

Azinuszellkarzinome (ACC) des Pankreas sind seltene Varianten des duktalen Adenokarzinoms des Pankreas. Die Chirurgie ist die einzige kurative Therapieoption und Protokolle für palliative Chemotherapien sind in diesem Zusammenhang noch nicht standardisiert. Wir berichten über einen 63-jährigen, weißen Patienten, der sich mit schmerzlosen Ikterus, Gewichtsverlust, erhöhtem Bilirubin sowie einem Pankreaskopftumor und Lebermetastase vorstellte. Die bioptische Sicherung der Pankreasläsion ergab den Nachweis eines ACC. Eine Therapie mit FOLFIRINOX führte zu einer signifikanten Verkleinerung des Primärtumors und einer Rückläufigkeit der Lebermetastase. Unser Fallbericht zeigt, dass FOLFIRINOX eine gut verträgliche Therapiemöglichkeit des inoperablen ACC darstellt und möglicherweise überlegen zu anderen chemotherapeutischen Substanzen ist .

Schlüsselwörter

Azinuszellkarzinom (ACC) - FOLFIRINOX - Pankreas

Key words

acinar cell carcinoma (ACC) - FOLFIRINOX - pancreas
 

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