J Knee Surg 2014; 27(04): 295-302
DOI: 10.1055/s-0033-1361951
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Evaluation of Synthetic Osteochondral Implants

James L. Cook
1   Comparative Orthopaedic Laboratory and Missouri Orthopaedic Institute, University of Missouri, Columbia, Missouri
,
Keiichi Kuroki
1   Comparative Orthopaedic Laboratory and Missouri Orthopaedic Institute, University of Missouri, Columbia, Missouri
,
Chantelle C. Bozynski
1   Comparative Orthopaedic Laboratory and Missouri Orthopaedic Institute, University of Missouri, Columbia, Missouri
,
Aaron M. Stoker
1   Comparative Orthopaedic Laboratory and Missouri Orthopaedic Institute, University of Missouri, Columbia, Missouri
,
Ferris M. Pfeiffer
1   Comparative Orthopaedic Laboratory and Missouri Orthopaedic Institute, University of Missouri, Columbia, Missouri
,
Cristi R. Cook
1   Comparative Orthopaedic Laboratory and Missouri Orthopaedic Institute, University of Missouri, Columbia, Missouri
› Institutsangaben
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Publikationsverlauf

23. Mai 2013

27. Oktober 2013

Publikationsdatum:
26. November 2013 (online)

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Abstract

This translational animal model study was designed to assess function, bone ingrowth and integration, and joint pathology associated with two different synthetic, bilayered osteochondral implants over a 3-month period after implantation into the femoral condyles of dogs. SynACart-Titanium (n = 6) and SynACart-PEEK (n = 6) (Arthrex, Naples, FL, and Sites Medical, Columbia City, IN) implants were press-fit into the lateral or medial femoral condyle (alternating location) of purpose-bred adult research dogs. Dogs were humanely euthanized 3 months after surgery and the operated knees were assessed radiographically, arthroscopically, grossly, and histologically. Based on all assessments, both types of implants were well tolerated and safe with no evidence for infection, migration, or rejection. Half of the SynACart-PEEK implants showed radiographic and histologic evidence of poor incorporation with all of these being in the lateral femoral condyle. SynACart-Titanium implants were considered effective in terms of integration into bone, lack of damage to surrounding and apposing articular cartilage, and maintenance of implant integrity and architecture for the duration of the study.