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Kardiologie up2date 2014; 10(01): 25-46
DOI: 10.1055/s-0034-1365447
Herzinsuffizienz
© Georg Thieme Verlag KG Stuttgart · New York

Herzinsuffizienz mit erhaltener LV-Funktion

Frank Edelmann
,
Rolf Wachter
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Publication Date:
10 April 2014 (online)

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Abstract

Heart failure continues to be a major health problem in the community. Nearly half the patients suffering from signs and symptoms of heart failure have a preserved left ventricular function but an evidence of diastolic dysfunction. Over the past decades the relative proportion of patients with heart failure and preserved ejection fraction (HFpEF) was continuously increasing which may reflect the change in the composite of risk factors in the ageing population. Comparable to heart failure with reduced ejection fraction (HFrEF), patients with HFpEF are characterised by a considerable morbidity and mortality. The recommendations of the European Society of Cardiology (ESC) on how to diagnose heart failure with normal or preserved ejection fraction allow diagnosing this highly relevant disease in a standardised manner. Because large clinical trials failed to show a prognostic benefit of approaches with proven efficiency in HFrEF, no evidence-based therapy is established in this condition. To improve the appreciation of heart failure with preserved ejection fraction, this article reviews the current epidemiologic, pathophysiologic, diagnostic and therapeutic aspects of this highly relevant disease.

 

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